Rituximab by subcutaneous route

Expert Review of Hematology
Philippe Solal-Celigny

Abstract

Rituximab has become a keystone of the treatment of B-cell lymphoproliferation. The standard administration route is intravenous infusion with risks of infusion-related reactions. In order to make administration easier, increase convenience for the patient and improve cost effectiveness, a subcutaneous (sc.) form has recently been developed. Early phase clinical studies in patients with follicular lymphoma have shown that a fixed dose of 1400 mg by sc. route yielded at least non-inferior pharmacokinetics that are at least as good as those of intravenous rituximab, as measured by Ctrough levels. The safety profile was also comparable. Preliminary analyses of clinical efficacy showed at least non-inferior response rates. Although additional information is required, these results suggest that sc. rituximab may become a useful option for treating patients with B-cell non-Hodgkin's lymphoma.

References

Jul 1, 2004·Blood·Guillaume CartronPhilippe Solal-Celigny
Mar 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J KeatingHagop Kantarjian
Mar 31, 2010·Clinical Journal of Oncology Nursing·Wendy H Vogel
Nov 13, 2013·Nature Reviews. Clinical Oncology·Mark RoschewskiWyndham H Wilson
Mar 1, 2014·Leukemia·W Hiddemann, B D Cheson
May 14, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio SalarGayane Tumyan

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Citations

Jul 26, 2018·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Beate BittnerJohannes Schmidt

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