Rituximab effect in severe progressive connective tissue disease-related lung disease: preliminary data.

Rheumatology International
Alejandro Robles-PerezJavier Narváez

Abstract

Progressive connective tissue disease (CTD)-related lung disease is a challenging condition that requires lung transplantation in some patients. Treatment with rituximab may improve lung function. To evaluate the effect of rituximab in patients with progressive CTD-related lung disease who met criteria for inclusion in waiting list for a lung transplant. Retrospective study of patients with progressive CTD-related lung disease with criteria for lung transplant (FVC < 60% and/or DLCO < 40%) that started treatment with rituximab because of disease progression. Clinical variables, pulmonary function tests and chest computed tomography were used to monitor the effect of rituximab. The cohort included 18 patients; systemic sclerosis (7), rheumatoid arthritis (5), systemic lupus erythematosus (4), Sjögren syndrome (1) and antisynthetase syndrome (1). The radiologic patterns observed were: usual interstitial pneumonia (1), non-specific interstitial pneumonia (9), lymphoid interstitial pneumonia (1), emphysema-usual interstitial pneumonia (1), shrinking lung syndrome (3) and undetermined pattern (3). Over the previous year to rituximab initiation a decline in FVC (- 3.8%, p = 0.095) and DLCO (- 8.4%, p = 0.004) was observed. After 2 ye...Continue Reading

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Jul 14, 2020·Current Opinion in Pulmonary Medicine·Amornpun WongkarnjanaMartin R J Kolb
Apr 4, 2021·Pharmaceuticals·Salvatore Di BartolomeoFrancesco Carubbi
Aug 27, 2021·Expert Opinion on Drug Safety·Esther F Vicente-RabanedaSantos Castañeda

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