Rituximab for adolescents with haemophilia and high titre inhibitors

Haemophilia : the Official Journal of the World Federation of Hemophilia
R A FoxC M Bennett

Abstract

Neutralizing alloantibodies (inhibitors) to factor VIII or factor IX develop in approximately 25% of patients with haemophilia A and <3% of patients with haemophilia B treated with factor concentrate. Patients with high titre inhibitors, in whom immune tolerance therapy fails, have few treatment options. Targeted anti-B-cell therapy with rituximab (chimeric anti-CD20) has been useful in several antibody-mediated autoimmune states. Case reports of rituximab treatment in small numbers of haemophilia patients with inhibitors have been inconclusive. We describe three adolescent patients with severe haemophilia and inhibitors treated with four weekly doses of rituximab, 375 mg m(-2). Treatment with rituximab was effective in reducing the inhibitor titre in two of three patients. Rituximab may be beneficial for patients with severe haemophilia and inhibitors in whom standard therapies have failed, but larger prospective studies are required to determine safety, efficacy and predictors of success.

References

Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I M NilssonO Zettervall
Jul 1, 1997·Annals of Hematology·S Sallah
Nov 12, 1998·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·V R DharnidharkaH W Harris
Oct 18, 2002·Blood·Adrian WiestnerGeraldine P Schechter
Oct 31, 2002·British Journal of Haematology·Sam KainMichael F Leahy
Jun 28, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·J WightC Knight
Nov 15, 2003·The Journal of Pediatrics·Bryce A BinstadtRobert P Sundel
Feb 4, 2005·The Journal of Pediatrics·Julie WangJames B Bussel
Jan 18, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·M CarcaoUNKNOWN Inhibitor Subcommittee of Association of Hemophilia Clinic Directors of Canada

❮ Previous
Next ❯

Citations

May 9, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Federico MingozziKatherine A High
Jan 8, 2008·Journal of Pediatric Hematology/oncology·Sarah AlexanderAkhilesh Chouksey
Sep 30, 2008·Blood·Christine L Kempton, Gilbert C White
Oct 27, 2010·Expert Review of Hematology·Carol H Miao
Feb 2, 2010·Hematology/oncology Clinics of North America·Nidra I Rodriguez, W Keith Hoots
Apr 3, 2008·Pediatric Clinics of North America·Nidra I Rodriguez, W Keith Hoots
Mar 27, 2007·The Journal of Pediatrics·Lisa B GiulinoUNKNOWN Pediatric and Platelet Immunology Committees of the TMH Clinical Trial Network
Mar 27, 2007·The Journal of Pediatrics·Moussa El-HallakRobert P Sundel
Jun 13, 2014·Thrombosis and Haemostasis·C LeissingerS F Assmann
Mar 27, 2009·Journal of Thrombosis and Haemostasis : JTH·P W CollinsUNKNOWN UK Haemophilia Centre Doctors' Organisation
Aug 2, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·M FranchiniM Cruciani
Oct 22, 2008·Pediatric Blood & Cancer·Brigitta U MuellerUNKNOWN Glaser Pediatric Research Network
Dec 18, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·D KlarmannW Kreuz
Jul 7, 2007·British Journal of Haematology·Donna DiMichele
Aug 21, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·D M DiMicheleE Santagostino
Nov 20, 2012·British Journal of Haematology·Peter W CollinsUNKNOWN UK Haemophilia Centre Doctors
Aug 29, 2012·British Journal of Haematology·Donna M DiMichele
Aug 4, 2011·Journal of Thrombosis and Haemostasis : JTH·D M Di Michele
Mar 19, 2014·British Journal of Haematology·Massimo Franchini, Pier Mannuccio Mannucci
Dec 21, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·J OldenburgE Santagostino
Oct 23, 2016·Thrombosis Research·K HolsteinUNKNOWN European Haemophilia Therapy Strategy Board (EHTSB)
Jul 8, 2017·The Cochrane Database of Systematic Reviews·Lucan JiangArmando Rodriguez
Aug 8, 2020·The Cochrane Database of Systematic Reviews·Lucan JiangArmando Rodriguez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Haemophilia : the Official Journal of the World Federation of Hemophilia
M CarcaoInhibitor Subcommittee of Association of Hemophilia Clinic Directors of Canada
Haemophilia : the Official Journal of the World Federation of Hemophilia
M MoschoviF Tzortzatou-Stathopoulou
Haemophilia : the Official Journal of the World Federation of Hemophilia
P W Collins
© 2022 Meta ULC. All rights reserved