Rituximab for retroperitoneal fibrosis due to IgG4-related disease: A case report and literature review

Clinical Nephrology. Case Studies
Mohammad AlmeqdadiBertrand L Jaber

Abstract

Retroperitoneal fibrosis (RPF) is a progressive fibroinflammatory disease that can be complicated by urinary obstruction. RPF can be the only manifestation of IgG4-related disease (IgG4-RD). Treatment of IgG4-related RPF is challenging and mostly consists of long-term glucocorticoids leading to significant side effects and treatment intolerance. Recent exploration of the role of rituximab as a B-cell depleting therapy in the treatment of IgG4-RD provides therapeutic potential as a well-tolerated alternative to glucocorticoids. We present a case of IgG4-related RPF for which rituximab was instituted as a steroid-sparing treatment strategy. Following 4 doses, kidney function partially recovered, and the disease went into remission. We discuss the potential merit of rituximab for the treatment of patients with IgG4-related RPF.

Citations

Sep 21, 2018·Current Opinion in Otolaryngology & Head and Neck Surgery·James Johnston, Jacqui E Allen
Jun 6, 2021·Journal of Investigative Medicine High Impact Case Reports·Syed Arqum HudaDavid Landsberg

Jul 31, 2020·La Revue de médecine interne·Alexandre Le JoncourPatrice Cacoub

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Methods Mentioned

BETA
electrophoreses
ESR
biopsy

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