Rituximab in a child with autoimmune thrombotic thrombocytopenic purpura refractory to plasma exchange.

International Journal of Hematology
Parameswaran NarayananSreejith Parameswaran

Abstract

A nine-year-old girl presented with headache, purpura and mild left hemiparesis. Laboratory evaluation revealed thrombotic microangiopathy with ADAMTS13 deficiency, with auto-antibodies to ADAMTS13. She was treated with plasma exchange and steroids, following which she improved transiently, relapsing within 2 months. The relapse was refractory to conventional therapy and rituximab was tried. She had good response to rituximab and has been in remission for the past 12 months. Rituximab may be a promising option for children with acquired TTP refractory to plasma exchange and steroids.

References

Nov 25, 2004·Hematology·J Evan SadlerJames N George
May 13, 2006·Journal of Thrombosis and Haemostasis : JTH·J A Kremer HovingaB Lämmle
Oct 3, 2006·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C CurtilletG Michel
Feb 28, 2007·Hematology·Massimo Franchini
Dec 3, 2008·Therapeutische Umschau. Revue thérapeutique·Birsen Arici, Marten Trendelenburg
Apr 29, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jumana H AlbaramkiStephen I Alexander
Jun 23, 2009·Pediatric Blood & Cancer·Maria C BouwNicole L Ramakers-van Woerden
May 18, 2010·Pediatric Hematology and Oncology·Somasundaram JayaboseClaudio Sandoval
Jul 14, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jérôme HarambatOlivier Brissaud

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Citations

Dec 25, 2012·Indian Journal of Pediatrics·Somasundaram JayaboseClaudio Sandoval
Dec 19, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Senthilkumar SankararamanHassan Ibrahim
Feb 21, 2013·Current Opinion in Pediatrics·Chantal LoiratAgnès Veyradier

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