Rituximab in children with resistant idiopathic nephrotic syndrome.

Journal of the American Society of Nephrology : JASN
Alberto MagnascoGian Marco Ghiggeri

Abstract

Idiopathic nephrotic syndrome resistant to standard treatments remains a therapeutic dilemma in pediatric nephrology. To test whether the anti-CD20 monoclonal antibody rituximab may benefit these patients, we conducted an open-label, randomized, controlled trial in 31 children with idiopathic nephrotic syndrome unresponsive to the combination of calcineurin inhibitors and prednisone. All children continued prednisone and calcineurin inhibitors at the doses prescribed before enrollment, and one treatment group received two doses of rituximab (375 mg/m(2) intravenously) as add-on therapy. The mean age was 8 years (range, 2-16 years). Rituximab did not reduce proteinuria at 3 months (change, -12% [95% confidence interval, -73% to 110%]; P=0.77 in analysis of covariance model adjusted for baseline proteinuria). Additional adjustment for previous remission and interaction terms (treatment by baseline proteinuria and treatment by previous remission) did not change the results. In conclusion, these data do not support the addition of rituximab to prednisone and calcineurin inhibitors in children with resistant idiopathic nephrotic syndrome.

References

Jun 1, 1993·Kidney International·C PonticelliF Locatelli
Jan 1, 1997·Ryōikibetsu shōkōgun shirīzu·I Kihara
Apr 16, 1998·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Y KimH S Lee
Dec 10, 1999·Controlled Clinical Trials·R Wolfe, J B Carlin
Jul 18, 2001·Current Opinion in Nephrology and Hypertension·K Tryggvason, J Wartiovaara
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Gianluca CaridiGian Marco Ghiggeri
Apr 9, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kerstin BenzDaniel Stachel
Jun 18, 2004·The New England Journal of Medicine·Jonathan C W EdwardsTim Shaw
Apr 9, 2005·Pediatric Research·Gianluca CaridiGian Marco Ghiggeri
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Flavio Vincenti, Gian Marco Ghiggeri
Aug 16, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Filippo AucellaGian Marco Ghiggeri
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jun YanMark J Mamula
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Piero RuggenentiGiuseppe Remuzzi
Oct 19, 2007·Kidney International·F C FervenzaD C Cattran
Dec 18, 2007·Nature Medicine·Changli WeiJochen Reiser
May 10, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vincent GuigonisFrançois Bouissou
Sep 19, 2008·Journal of the American Society of Nephrology : JASN·David Jayne
Dec 11, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gianluca CaridiGian Marco Ghiggeri
Jan 10, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maddalena GiganteLoreto Gesualdo
Apr 28, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marie-Camille ChaumaisGeorges Deschênes
Jul 7, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Gema Fernandez-FresnedoUNKNOWN Trabajo de Enfermedades Glomerulares de la Sociedad Española de Nefrología (GLOSEN)
Sep 11, 2009·The New England Journal of Medicine·Yiping ChenIgor J Koralnik
Dec 25, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Agnieszka PrytułaKjell Tullus
Aug 28, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ashima GulatiArvind Bagga
Mar 15, 2011·Arthritis and Rheumatism·Frank L van de VeerdonkLeo A B Joosten
May 14, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Pietro RavaniGian Marco Ghiggeri
Jun 3, 2011·Science Translational Medicine·Alessia FornoniGeorge W Burke
Jul 8, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Maddalena GiganteLoreto Gesualdo
Jul 19, 2011·Clinical and Experimental Immunology·R BertelliG M Ghiggeri
Aug 2, 2011·Nature Medicine·Changli WeiJochen Reiser
Feb 22, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Pietro RavaniUNKNOWN Alberta Kidney Disease Network

❮ Previous
Next ❯

Citations

Sep 21, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kjell Tullus, Stephen D Marks
Oct 12, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Shuichi ItoKazumoto Iijima
Jan 15, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yuko HamasakiUNKNOWN for Japanese Study Group of Renal Disease in Children
May 2, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Caroline StraatmannV Matti Vehaskari
Aug 7, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Susan SamuelMichael Zappitelli
Oct 19, 2013·Biologicals : Journal of the International Association of Biological Standardization·Mirco BelingheriLuciana Ghio
Jan 23, 2013·Nature Reviews. Nephrology·Aditi Sinha, Arvind Bagga
Mar 29, 2014·The New England Journal of Medicine·Biswanath Basu
Jul 4, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Markus J KemperJun Oh
Feb 7, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Koichi KameiShuichi Ito
Mar 13, 2014·Nature Reviews. Nephrology·John Feehally
Jun 25, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gabriel Cara-FuentesEduardo H Garin
Jun 13, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joëlle GuitardDominique Chauveau
Jan 10, 2014·Seminars in Immunopathology·Djillali SahaliAndre Pawlak
Nov 6, 2013·Expert Opinion on Biological Therapy·Anisha TannaCharles D Pusey
Mar 8, 2014·Advances in Chronic Kidney Disease·Christine B Sethna, Debbie S Gipson
Mar 8, 2014·Advances in Chronic Kidney Disease·Ilse M RoodJack F M Wetzels
Jan 16, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Susan SamuelNorman Muirhead
Nov 19, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jonathan HoganGerald B Appel
Sep 25, 2012·Autoimmunity Reviews·Andrea G KattahDario Roccatello
Mar 1, 2013·Kidney International·Richard J Glassock
Sep 15, 2015·Revista chilena de pediatría·Pilar HeviaUNKNOWN en representación de la Rama de Nefrología de la Sociedad Chilena de Pediatría
Jun 5, 2015·Nephrology·See Cheng Yeo, Adrian Liew
Sep 13, 2015·Revista chilena de pediatría·Pilar HeviaUNKNOWN En Representación de la Rama de Nefrología de la Sociedad Chilena de Pediatría
Nov 21, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Pietro RavaniGian Marco Ghiggeri
Oct 1, 2014·Journal of Paediatrics and Child Health·David Kieran Metz, Joshua Yehuda Kausman
Jun 10, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Clare E CounsilmanRam N Sukhai
Mar 6, 2015·Current Pediatrics Reports·Kazumoto IijimaKandai Nozu
Feb 6, 2015·Clinical and Experimental Nephrology·Kenji IshikuraUNKNOWN Japanese Society for Pediatric Nephrology
Aug 15, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aditi SinhaArvind Bagga
Jun 9, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Chang-Yien ChanHui-Kim Yap
Jul 17, 2016·Clinical and Experimental Nephrology·Kazumoto IijimaKandai Nozu
Aug 31, 2016·Nature Reviews. Nephrology·Luca PericoGiuseppe Remuzzi
Oct 27, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Samriti Dogra, Frederick Kaskel
Nov 3, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Taku NakagawaRyojiro Tanaka
Mar 21, 2017·American Journal of Nephrology·Landon C BrownWilliam F Pendergraft
Feb 14, 2018·British Journal of Clinical Pharmacology·Alice BonanniGian Marco Ghiggeri
Jan 18, 2018·Journal of Clinical Apheresis·Maiko TakakuraAkihiro Yachie
May 15, 2012·Journal of the American Society of Nephrology : JASN·Madhura Pradhan, Susan Furth
Feb 1, 2014·Journal of the American Society of Nephrology : JASN·Piero RuggenentiUNKNOWN Rituximab in Nephrotic Syndrome of Steroid-Dependent or Frequently Relapsing Minimal Change Disease Or Focal Segmental Glome
Jan 17, 2015·Journal of the American Society of Nephrology : JASN·Pietro RavaniGian Marco Ghiggeri
Jun 13, 2012·Nature Reviews. Nephrology·Larry A GreenbaumWilliam E Smoyer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.