Rituximab in refractory pemphigus vulgaris

Dermatologic Therapy
M SorceMaria Rita Bongiorno

Abstract

Pemphigus vulgaris (PV) is a severe chronic autoimmune blistering disease of skin and mucous membranes. The use of systemic corticosteroids in pemphigus has dramatically reduced its mortality rate, but the long-term use of steroids leads to severe side effects, many of which are serious. For this reason it is often necessary to add immunosuppressive agents to the regimen. However, there are occasional refractory cases in which therapy with conventionally accepted modalities is either not efficacious or not possible on account of side effects. Rituximab is a therapeutic monoclonal antibody targeting CD20, an integral membrane protein highly expressed on the surface of pre-B lymphocytes and activated mature B lymphocytes. We present an instance of refractory PV successfully treated with rituximab. The successful treatment of pemphigus described here demonstrates that rituximab is a viable therapeutic option for patients with refractory PV.

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Citations

Dec 4, 2012·Dermatology and Therapy·Labib R ZakkaA Razzaque Ahmed
Sep 18, 2009·Annals of the New York Academy of Sciences·Enno SchmidtDetlef Zillikens
Jun 26, 2013·International Journal of Dermatology·Kamran BalighiChams-Davatchi Cheyda
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May 25, 2021·The Journal of Dermatological Treatment·Burçin Cansu BozcaSoner Uzun

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