Rituximab in refractory sarcoidosis: a single centre experience

Clinical and Molecular Allergy : CMA
Francesco CinettoCarlo Agostini

Abstract

Sarcoidosis is a granulomatous disease whose outcome varies from spontaneous remission to chronic refractory disease. Provided that steroids represent the gold standard as a first line treatment, many immune suppressants drugs are currently used in the disease management. However, refractory disease is still a great challenge. Rituximab is an anti-CD20 chimeric monoclonal antibody, currently used for the treatment of B cell malignancies and systemic autoimmune diseases. There are few case reports describing the successful use of Rituximab in refractory sarcoidosis with lung, eye, lymph nodes and skin involvement. In this paper we described three different case reports in which Rituximab has been used to treat refractory sarcoidosis and we reviewed the existing literature.

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Citations

Feb 22, 2016·La Revue de médecine interne·Y UzunhanH Nunes
Mar 10, 2016·Expert Review of Respiratory Medicine·Ying ZhouRobert P Baughman
Apr 22, 2016·Expert Review of Clinical Immunology·Francesco Cinetto, Carlo Agostini
Jun 9, 2018·Expert Review of Clinical Pharmacology·W Ennis James, Robert Baughman
Jul 10, 2018·Current Opinion in Pulmonary Medicine·Peter KorstenElena Nikiphorou
Aug 31, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Francesco CinettoCarlo Agostini
Jul 31, 2019·Expert Review of Respiratory Medicine·Francesco CinettoCinzia Milito
Aug 1, 2019·Current Opinion in Pulmonary Medicine·Hilario NunesDominique Valeyre
Feb 1, 2020·Expert Review of Respiratory Medicine·W Ennis James, Marc A Judson
Oct 17, 2017·Neurology·Jeffrey M GelfandSiddharama Pawate
Dec 24, 2019·Expert Review of Respiratory Medicine·Aman Pande, Daniel A Culver
Aug 3, 2020·Current Opinion in Pulmonary Medicine·Divya C Patel, Dominique Valeyre
Jul 24, 2020·Current Opinion in Pulmonary Medicine·Francesco CinettoMark G Jones
Jul 6, 2016·Current Opinion in Pulmonary Medicine·Catherine A BonhamKaren C Patterson
Aug 8, 2020·Frontiers in Immunology·Raisa KraaijvangerMarcel Veltkamp
Jan 25, 2020·Scientific Reports·I KudryavtsevY Shoenfeld
May 28, 2020·Dermatologic Therapy·Nicole C VeselyMaria Isabel Longo
May 14, 2019·Clinical and Molecular Allergy : CMA·Antonio PecoraroGiuseppe Spadaro
Jul 6, 2019·Nature Reviews. Disease Primers·Johan GrunewaldJoachim Müller-Quernheim
May 6, 2020·Therapeutics and Clinical Risk Management·Thomas El JammalPascal Sève
Mar 22, 2019·American Journal of Clinical Dermatology·Christina DaiNaveed Sami
Mar 22, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Franck F RahaghiMary Beth Scholand
Dec 18, 2020·Frontiers in Medicine·Gonçalo BoletoPatrice Cacoub
Sep 6, 2019·Mayo Clinic Proceedings. Innovations, Quality & Outcomes·Patompong UngprasertEric L Matteson
Jan 26, 2021·Expert Review of Clinical Pharmacology·Ogugua Ndili ObiRobert P Baughman
Jul 29, 2021·Journal of Cardiac Failure·Mohamed ElwazirShreyasee Amin
Aug 25, 2021·Indian Journal of Ophthalmology·Swati PhuljheleRohit Saxena

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Methods Mentioned

BETA
X-ray
bronchoalveolar lavage
biopsies

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