Rituximab-induced lung disease: A systematic literature review

The European Respiratory Journal
H LiotéJ Cadranel

Abstract

The anti-CD20 antibody rituximab has been reported to induce a heterogeneous spectrum of lung disorders. The aim of the present study was to critically review data on the clinical presentations, causality assessments and management strategies of lung diseases possibly related to rituximab. A systematic literature review was performed on English-language reports in PubMed until September 2008. Cases of lung diseases ascribed to rituximab (n = 45) were identified, with three time-to-onset patterns. The most common presentation was acute/subacute hypoxaemic organising pneumonia (n = 37), starting 2 weeks after the last infusion (often around the fourth cycle) and resolving, in most cases, provided glucocorticoid therapy was given early. Acute respiratory distress syndrome occurred in five patients, within a few hours and usually after the first infusion. In the remaining three patients, macronodular organising pneumonia developed insidiously long after rituximab therapy and responded to steroids. Eight patients died. Based on time to onset, symptoms, and responses to discontinuation and rechallenge with rituximab and other drugs, 13 cases were highly compatible and 32 compatible with rituximab-induced lung disease. Knowledge of th...Continue Reading

Citations

Feb 9, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Martin BitzanLorraine E Bell
Nov 5, 2013·Revue de pneumologie clinique·L Essaadouni, L Benjilali
Dec 14, 2011·Rheumatology·Andreas V HadjinicolaouAndrew J K Ostör
Jul 21, 2012·Annals of Intensive Care·Mohamad ZaidanElie Azoulay
Dec 25, 2013·Nature Reviews. Rheumatology·Meghna JaniWilliam G Dixon
May 3, 2011·The American Journal of Medicine·Manuel Ramos-CasalsUNKNOWN BIOGEAS Study Group
Sep 6, 2011·Rheumatology International·Mortimer B O'ConnorMark J Phelan
Dec 2, 2010·Journal of Cancer Research and Therapeutics·Murali SubramanianK N Mohan Rao
Nov 15, 2011·Targeted Oncology·Nicholas A Barber, Apar Kishor Ganti
Feb 13, 2016·Pulmonary Pharmacology & Therapeutics·Daniel FranzenMalcolm Kohler
Aug 22, 2015·Expert Opinion on Drug Metabolism & Toxicology·Laure-Anne TeuwenLuc Dirix
Jul 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Perrine CréquitJacques Cadranel
Nov 10, 2012·Rheumatic Diseases Clinics of North America·Ashima MakolEric L Matteson
Jun 30, 2012·Pathologie-biologie·S AissiH Boussen
Sep 13, 2011·Journal of Autoimmunity·Andrea T BorchersM Eric Gershwin
Feb 1, 2011·Seminars in Arthritis and Rheumatism·Roberto Perez-AlvarezManuel Ramos-Casals
Jul 11, 2012·Case Reports in Medicine·Ahmet B ErginHamed A Daw
Aug 19, 2014·Journal of Clinical Pharmacy and Therapeutics·H KongS Dai
Oct 31, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Toshimitsu IreiHideki Ohdan
Oct 8, 2011·Clinical Lymphoma, Myeloma & Leukemia·Harumi KatoYasuo Morishima
Jun 16, 2015·BioMed Research International·Mei GuanShu-Chang Chen
Apr 4, 2015·Rheumatic Diseases Clinics of North America·Zulma X Yunt, Joshua J Solomon
Apr 28, 2016·Expert Review of Clinical Immunology·Yasunari MiyazakiNaohiko Inase
Jun 23, 2016·The British Journal of Radiology·Chong Hyun SuhAtul B Shinagare
Dec 14, 2012·Respiration; International Review of Thoracic Diseases·Seung-Ick ChaJae-Yong Park
Nov 12, 2015·European Clinical Respiratory Journal·Matiuallah NaqibullahElisabeth Bendstrup
Feb 2, 2018·Clinical Rheumatology·Matthew KoslowIssahar Ben-Dov
Aug 16, 2017·Rheumatology and Therapy·James BluettDeborah P M Symmons
Dec 2, 2015·Therapeutic Advances in Musculoskeletal Disease·Kundan Iqbal, Clive Kelly
Sep 12, 2013·Tuberculosis and Respiratory Diseases·Yong Hyun Kim, Soon Seog Kwon
Aug 23, 2018·Breathe·Maria BolakiKaterina M Antoniou
Feb 19, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Effrossyni Gkrania-Klotsas, Dinakantha S Kumararatne
Apr 20, 2018·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Babina GosangiKatherine Krajewski
Apr 2, 2019·Frontiers in Medicine·Theodoros KarampitsakosArgyris Tzouvelekis

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