Rituximab-it was the best of times, it was the worst of times

Autoimmunity Reviews
David A Isenberg

Abstract

B cell depletion (BCD) has become established in the treatment of patients with rheumatoid arthritis (RA) vasculitis and systemic lupus erythematosus (SLE). However, although successfully confirmed to be useful in major large scale trials in RA and vasculitis, two SLE trials did not meet their endpoints. Given the widespread use of BCD in SLE it seems likely that it will continue to be used though better designed trials (which work) would help resolve on-going problems with regulatory and funding agencies.

References

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Apr 17, 2009·Journal of the American Society of Nephrology : JASN·Gerald B AppelUNKNOWN Aspreva Lupus Management Study Group
Dec 1, 2009·Nature Reviews. Rheumatology·Catarina Favas, David A Isenberg
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May 14, 2011·Autoimmunity Reviews·Guillermo J Pons-EstelRicard Cervera

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Citations

Apr 11, 2013·Immunologic Research·Francesco CasoAndrea Doria
Jun 25, 2013·Revista clínica española·J Jiménez-AlonsoJ M Sabio
Sep 19, 2012·Autoimmunity Reviews·Renato A Sinico, Pierluigi Meroni
Mar 30, 2016·Nature Reviews. Drug Discovery·James N Fullerton, Derek W Gilroy
Nov 22, 2015·Rheumatology·Claire-Louise MurphyDavid Isenberg
Jul 15, 2015·Autoimmunity Reviews·Manfred RelleAndreas Schwarting
Jul 28, 2016·Immunologic Research·Roberta FenoglioDario Roccatello
Aug 2, 2013·Therapeutic Advances in Musculoskeletal Disease·Vijay Rao, Simon Bowman
May 1, 2017·Clinical Reviews in Allergy & Immunology·Taher E TaherRizgar A Mageed

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