Rituximab Therapy for Childhood Pemphigus Vulgaris

Pediatric Dermatology
Leah Kincaid, Miriam Weinstein

Abstract

Pediatric pemphigus vulgaris (PV) is a rare autoimmune bullous dermatosis that poses a diagnostic and therapeutic challenge. Rituximab, an anti-CD20 monoclonal antibody, is an important medication in adult PV but has rarely been used to treat pediatric disease. We describe successful rituximab therapy in a 4-year-old, the youngest patient with PV ever reported to receive rituximab. A live attenuated vaccination was later given without incident. We also review rituximab clinical outcomes, toxicity, dosing protocols, and relapse in children with PV.

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Citations

Dec 2, 2017·The British Journal of Dermatology·K E HarmanP D Yesudian
Sep 12, 2019·Paediatric Drugs·Brittney Schultz, Kristen Hook

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