Rituximab therapy for thrombotic thrombocytopenic purpura: a proposed study of the Transfusion Medicine/Hemostasis Clinical Trials Network with a systematic review of rituximab therapy for immune-mediated disorders

Journal of Clinical Apheresis
James N GeorgeSara K Vesely

Abstract

The rationale for immunosuppressive therapy of thrombotic thrombocytopenic purpura (TTP) was established by observations that TTP may be caused by autoantibodies to ADAMTS13. Patients with high-titer autoantibodies to ADAMTS13 may have a higher mortality, and survivors may require prolonged plasma exchange therapy in spite of adjunctive glucocorticoid treatment. More intensive immunosuppressive therapy with rituximab may provide benefit for many of these patients. The Transfusion Medicine/Hemostasis Clinical Trials Network is developing a randomized, clinical trial to test the hypothesis that addition of rituximab to standard treatment of TTP with plasma exchange and glucocorticoids will decrease initial treatment failure rates as well as subsequent relapses over the following 3 years. To provide the background data for this clinical trial, a systematic review of all published reports on rituximab treatment of immune-mediated disorders was performed. Twelve articles have reported 27 patients treated with rituximab for TTP, with benefit described in 25 (93%) of the patients. Additional reports have described rituximab treatment of 37 other immune-mediated disorders, with clinical response in most patients. These observations fro...Continue Reading

References

Mar 1, 1997·Annals of Internal Medicine·D J CookR B Haynes
Apr 20, 2001·Journal of Clinical Apheresis·Z R ZeiglerUNKNOWN North American TTP Group
Aug 23, 2002·The New England Journal of Medicine·Joel L Moake
Sep 14, 2002·Annals of the Rheumatic Diseases·M J LeandroG Cambridge
Sep 28, 2002·American Journal of Hematology·Jens ChemnitzDietmar Söhngen
Oct 2, 2002·Lancet·Giuseppe RemuzziPiero Ruggenenti
Oct 9, 2002·Blood Cells, Molecules & Diseases·Lorence A GuttermanHan-Mou Tsai
Oct 18, 2002·Arthritis and Rheumatism·Maria J LeandroDavid A Isenberg
Jan 17, 2003·Annals of Internal Medicine·Xinglong ZhengMorey A Blinder
Feb 1, 2003·Blood·Francesco ZajaGianfranco Ferraccioli
Feb 28, 2003·European Journal of Haematology·Han-Mou Tsai, Keith Shulman
Mar 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·A PestronkT D Levine
Apr 23, 2003·Muscle & Nerve·Susanne RenaudAndreas J Steck
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Piero RuggenentiGiuseppe Remuzzi
Jul 5, 2003·Blood·Anne-Geneviève MarcelinNicolas Dupin
Jul 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·James M GloorMark D Stegall
Aug 22, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Voravit RatanatharathornJoseph P Uberti
Oct 1, 1962·British Journal of Haematology·M C BRAIND O HOURIHANE
Feb 19, 2004·Annals of Internal Medicine·Fadi FakhouriAgnès Veyradier
Mar 11, 2004·British Journal of Haematology·Roslyn YomtovianHan-Mou Tsai
Apr 22, 2004·Journal of Thrombosis and Haemostasis : JTH·S SallahN P Nguyen
May 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Yolanda T BeckerHans W Sollinger
May 28, 2004·Scandinavian Journal of Rheumatology·C KneitzH P Tony
Jun 18, 2004·The New England Journal of Medicine·Jonathan C W EdwardsTim Shaw
Jul 23, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Christopher J SonnendayRobert A Montgomery
Aug 6, 2004·International Journal of Hematology·Gideon Y SteinMoshe Mittelman
Sep 25, 2004·American Journal of Hematology·Afaq AhmadGeraldine P Schechter
Oct 21, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dario RoccatelloLuigi Massimino Sena
Nov 2, 2004·Annals of Hematology·Pavan S ReddyMervin A Sahud

❮ Previous
Next ❯

Citations

Oct 29, 2011·Medizinische Klinik, Intensivmedizin und Notfallmedizin·L Engelmann
Apr 28, 2010·Annals of Hematology·Jens Marcus ChemnitzChristof Scheid
Jun 25, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Chantal LoiratAgnès Veyradier
Apr 29, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jumana H AlbaramkiStephen I Alexander
Jan 9, 2010·International Journal of Hematology·Joseph E Kiss
May 5, 2006·The New England Journal of Medicine·James N George
Aug 30, 2008·Thyroid : Official Journal of the American Thyroid Association·J Paul BangaLaszlo Hegedus
Dec 24, 2011·Clinical Journal of the American Society of Nephrology : CJASN·William F Clark, Ainslie Hildebrand
Jan 1, 2010·Mediterranean Journal of Hematology and Infectious Diseases·Evi Stavrou, Hillard M Lazarus
Nov 6, 2009·Wiener klinische Wochenschrift·Lea SalamonJadranka Morovic-Vergles
Aug 7, 2010·Der Internist·M HellmannI Scharrer
May 1, 2008·Expert Review of Clinical Immunology·Luigi BartalenaMaria Laura Tanda
Dec 19, 2006·Expert Review of Cardiovascular Therapy·Han-Mou Tsai
May 12, 2009·Expert Opinion on Investigational Drugs·Donald M ArnoldJohn G Kelton
Mar 27, 2009·The American Journal of the Medical Sciences·Muralikrishna GopalJack B Alperin
Jun 5, 2012·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Li-Yan LinKuender D Yang
Jan 31, 2009·Kidney International. Supplement·Han-Mou Tsai
Dec 3, 2008·European Journal of Internal Medicine·Daan DierickxAndré Delannoy
Nov 21, 2007·La Revue de médecine interne·N SchleinitzJ R Harlé
Aug 2, 2007·Hematology/oncology Clinics of North America·Han-Mou Tsai
Feb 6, 2007·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Araba Afenyi-AnnanNicholas Bandarenko
Jan 29, 2008·European Journal of Haematology·James N GeorgeBernhard Lämmle
Oct 30, 2007·Pharmacotherapy·Rami B IbrahimDavid J Edwards
Aug 21, 2008·Journal of Clinical Apheresis·Sushama JastiBernard Poiesz
Jul 12, 2008·Journal of Clinical Apheresis·James N GeorgeSara K Vesely
Aug 2, 2006·Journal of Thrombosis and Haemostasis : JTH·J N George
Feb 8, 2007·Journal of Clinical Apheresis·Wilmar Patino, Ravindra Sarode
Feb 18, 2011·American Journal of Hematology·Daan DierickxDrew Provan
Feb 26, 2013·British Journal of Clinical Pharmacology·Florent PuissetJacques Pourrat
Dec 25, 2009·Blood·Johanna A Kremer HovingaJames N George
Nov 13, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·John Fredy Nieto-RíosGustavo Zuluaga-Valencia

❮ Previous
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