Rituximab toxicity in patients with peripheral blood malignant B-cell lymphocytosis

Leukemia & Lymphoma
S KanelliT E Witzig

Abstract

Infusion related adverse events (AE) with day 1 rituximab in patients with B-cell non-Hodgkin's lymphoma (NHL) are common. The purpose of this study was to evaluate the AE occurring in patients with malignant B-cell lymphocytosis who received rituximab. Patients with a > or = 3 x 10(9)/L absolute lymphocyte count (ALC) receiving rituximab from 1998 to 1999 or participating in a phase I study of rituximab and interleukin-12 were reviewed. The AE occurring on the day of rituximab, the treatment provided (including hospitalization), and the subsequent ALC responses were recorded. Twenty-seven patients were identified; 14 had NHL, one Waldenstrom's macroglobulinemia, and 12 patients had chronic lymphocytic leukemia. The baseline median ALC was 9.58 x 10(9)/L (mean, 49.31; range, 3.56-380.95). All patients received rituximab as an outpatient. There were only two AE > or = grade 3. One patient was hospitalized for 1 day for i.v. fluids to treat an increase in creatinine that occurred with tumor lysis. A second patient developed a pulmonary syndrome five days after day 1 rituximab and required mechanical ventilation, but had no long-term lung toxicity. This study demonstrates that patients with high numbers of circulating blood B-lymp...Continue Reading

Citations

Sep 26, 2002·Pharmacoepidemiology and Drug Safety
Mar 2, 2011·Cancer Biotherapy & Radiopharmaceuticals·Robert O Dillman
Jul 26, 2011·International Journal of Nursing Practice·Dora S P LangAlan Pearson
Dec 18, 2009·Anti-cancer Drugs·Maajid Mumtaz PeerzadaHamed A Daw
Oct 30, 2004·Leukemia & Lymphoma·Doru T AlexandrescuPeter H Wiernik
Apr 28, 2006·Clinical Lymphoma & Myeloma·Yair HerishanuElizabeth Naparstek
Apr 22, 2008·Joint, Bone, Spine : Revue Du Rhumatisme·Huguette Lioté
Apr 20, 2011·Journal of Clinical Pharmacy and Therapeutics·P Bose, O Qubaiah
Aug 2, 2005·Cancer Treatment Reviews·Eva Kimby
Mar 17, 2010·Pediatric Pulmonology·Huguette LiotéFrédéric Lioté
Aug 24, 2006·Expert Review of Anticancer Therapy·Gerhard HeldMichael Pfreundschuh
Jan 23, 2015·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Frederico F SouzaNikhil Ramaiya

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

© 2022 Meta ULC. All rights reserved