Rituximab Treatment for Nephrotic Syndrome in Children.

Current Pediatrics Reports
Kazumoto IijimaKandai Nozu

Abstract

In the past 10 years, many reports have suggested that rituximab, a chimeric anti-CD20 monoclonal antibody, is effective for children with complicated, frequently relapsing or steroid-dependent nephrotic syndrome (FRNS/SDNS). However, those reports were case reports, case series, retrospective surveys, and single-arm or short-term trials. Therefore, well-designed controlled trials are required to establish the value of rituximab in this condition. To evaluate the efficacy and safety of rituximab in childhood-onset, complicated FRNS/SDNS, a multicenter, double-blind, randomized, placebo-controlled trial was carried out by the Research Group of Childhood-onset Refractory Nephrotic Syndrome (RCRNS) in Japan (RCRNS01). RCRNS01 showed that rituximab is safe and effective for the treatment of childhood-onset, complicated FRNS/SDNS. In 2014, the use of rituximab for patients with complicated FRNS/SDNS was approved, first in the world, by the Ministry of Health, Labour and Welfare, Japan.

References

Apr 1, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Y InoueN Yoshikawa
Aug 29, 2003·Lancet·Allison A Eddy, Jordan M Symons
Apr 9, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kerstin BenzDaniel Stachel
Jun 18, 2004·The New England Journal of Medicine·Jonathan C W EdwardsTim Shaw
Jun 7, 2005·Expert Opinion on Drug Safety·Yutaka TsutsumiNobuo Masauzi
Aug 2, 2005·Cancer Treatment Reviews·Eva Kimby
Sep 1, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kandai NozuMasafumi Matsuo
May 5, 2006·The New England Journal of Medicine·Mark D PescovitzRichard A Sidner
Aug 26, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rodney D GilbertSusan Rigden
Feb 21, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Graham C Smith
Mar 29, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Julia M HofstraJack F M Wetzels
Jun 29, 2007·The New England Journal of Medicine·Arvind BaggaAsha Moudgil
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Paolo CravediGiuseppe Remuzzi
Nov 2, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Makiko NakayamaKazumoto Iijima
Nov 24, 2007·Autoimmunity Reviews·Serena BugattiCarlomaurizio Montecucco
May 10, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vincent GuigonisFrançois Bouissou
Aug 30, 2008·Autoimmunity Reviews·Kui Liu, Chandra Mohan
Nov 21, 2008·Journal of the American Society of Nephrology : JASN·Ludmilla Le BerreJacques Dantal
Feb 4, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yuya HashimuraMasafumi Matsuo
Apr 28, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marie-Camille ChaumaisGeorges Deschênes
May 8, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Koichi KameiKazumoto Iijima
Jun 6, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Carlos ArayaEduardo Garin
Aug 29, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yuko HamasakiUNKNOWN Japanese Study Group of Renal Disease
Dec 22, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Koichi KameiKazumoto Iijima
Dec 25, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hiroshi KaitoShuichi Ito
Dec 25, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Agnieszka PrytułaKjell Tullus
Jun 10, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kenji IshikuraUNKNOWN for Japanese Study Group of Renal Disease in Children
Jun 23, 2010·Pediatrics·Daniela S ArdeleanSusanne M Benseler
Jul 22, 2010·The New England Journal of Medicine·John H StoneUNKNOWN RAVE-ITN Research Group
Aug 28, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ashima GulatiArvind Bagga
Nov 12, 2010·The Cochrane Database of Systematic Reviews·Elisabeth M HodsonJonathan C Craig
May 14, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Pietro RavaniGian Marco Ghiggeri
Jun 3, 2011·Science Translational Medicine·Alessia FornoniGeorge W Burke
May 15, 2012·Journal of the American Society of Nephrology : JASN·Alberto MagnascoGian Marco Ghiggeri
Sep 6, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mai SatoKentaro Matsuoka
Oct 12, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Shuichi ItoKazumoto Iijima
Jan 23, 2013·Nature Reviews. Nephrology·Aditi Sinha, Arvind Bagga
May 24, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anne-Laure Sellier-LeclercGeorges Deschênes
Oct 30, 2013·The Cochrane Database of Systematic Reviews·Nanthiya PravitsitthikulJonathan C Craig
Feb 1, 2014·Journal of the American Society of Nephrology : JASN·Piero RuggenentiUNKNOWN Rituximab in Nephrotic Syndrome of Steroid-Dependent or Frequently Relapsing Minimal Change Disease Or Focal Segmental Glome
Feb 7, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Koichi KameiShuichi Ito

❮ Previous
Next ❯

Citations

Jul 17, 2016·Clinical and Experimental Nephrology·Kazumoto IijimaKandai Nozu
Jun 10, 2016·Korean journal of pediatrics·Seong Heon KimJae Il Shin
Mar 1, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Avi Z Rosenberg, Jeffrey B Kopp
Dec 13, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Marina VivarelliFrancesco Emma
Apr 12, 2019·Pediatric Transplantation·Sonia SolomonMarcela Del Rio
Sep 8, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Markus J KemperMichael van Husen
Apr 17, 2020·The Cochrane Database of Systematic Reviews·Nicholas G LarkinsElisabeth M Hodson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.