Rituximab versus cyclophosphamide for ANCA-associated vasculitis.

The New England Journal of Medicine
John H StoneRAVE-ITN Research Group

Abstract

Cyclophosphamide and glucocorticoids have been the cornerstone of remission-induction therapy for severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis for 40 years. Uncontrolled studies suggest that rituximab is effective and may be safer than a cyclophosphamide-based regimen. We conducted a multicenter, randomized, double-blind, double-dummy, noninferiority trial of rituximab (375 mg per square meter of body-surface area per week for 4 weeks) as compared with cyclophosphamide (2 mg per kilogram of body weight per day) for remission induction. Glucocorticoids were tapered off; the primary end point was remission of disease without the use of prednisone at 6 months. Nine centers enrolled 197 ANCA-positive patients with either Wegener's granulomatosis or microscopic polyangiitis. Baseline disease activity, organ involvement, and the proportion of patients with relapsing disease were similar in the two treatment groups. Sixty-three patients in the rituximab group (64%) reached the primary end point, as compared with 52 patients in the control group (53%), a result that met the criterion for noninferiority (P<0.001). The rituximab-based regimen was more efficacious than the cyclophosphamide-based regimen for indu...Continue Reading

References

Mar 15, 1992·Annals of Internal Medicine·G S HoffmanA S Fauci
Apr 29, 1971·The New England Journal of Medicine·S N Novack, C M Pearson
Jun 1, 1983·Annals of Internal Medicine·J E Nestler
Feb 1, 1994·Arthritis and Rheumatism·J C JennetteC G Kallenberg
Mar 24, 1999·Arthritis and Rheumatism·L GuillevinB Jarrousse
May 18, 1999·The Journal of Allergy and Clinical Immunology·E R PopaJ W Tervaert
Apr 25, 2001·Arthritis and Rheumatism·J H StoneUNKNOWN International Network for the Study of the Systemic Vasculitides (INSSYS)
Mar 26, 2003·Seminars in Oncology·Peter Johnson, Martin Glennie
Jul 4, 2003·The New England Journal of Medicine·David JayneUNKNOWN European Vasculitis Study Group
Aug 9, 2003·Arthritis and Rheumatism·John H Stone, UNKNOWN Wegener's Granulomatosis Etanercept Trial Research Group
Aug 2, 1958·British Medical Journal·E W WALTON
May 15, 2004·Immunity·Flavius Martin, Andrew C Chan
Jan 28, 2005·The New England Journal of Medicine·UNKNOWN Wegener's Granulomatosis Etanercept Trial (WGET) Research Group
Apr 20, 2005·Current Opinion in Rheumatology·Oemer N Goek, John H Stone
Jun 28, 2005·Journal of Clinical Immunology·J G M C DamoiseauxJ W Cohen Tervaert
Oct 15, 2005·American Journal of Respiratory and Critical Care Medicine·Karina A KeoghUlrich Specks
Apr 29, 2006·Arthritis and Rheumatism·John H StoneUNKNOWN Wegener's Granulomatosis Etanercept Trial Research Group
Jul 3, 2007·The American Journal of Medicine·Javier D FinkielmanUNKNOWN WGET Research Group
Nov 23, 2007·The New England Journal of Medicine·Rui WangJeffrey M Drazen
Dec 26, 2008·The New England Journal of Medicine·Christian PagnouxUNKNOWN French Vasculitis Study Group
May 20, 2009·Annals of Internal Medicine·Kirsten de GrootUNKNOWN EUVAS (European Vasculitis Study Group)
Jul 22, 2010·The New England Journal of Medicine·Rachel B JonesUNKNOWN European Vasculitis Study Group
Feb 1, 2003·Seminars in Oncology·Peter Johnson, Martin Glennie

❮ Previous
Next ❯

Citations

Feb 22, 2012·Medizinische Klinik, Intensivmedizin und Notfallmedizin·P LehmannM Fleck
Jun 29, 2011·Annals of Hematology·Souleymane BrahJean-Marc Durand
Jul 23, 2011·Zeitschrift für Rheumatologie·E Reinhold-Keller, F Moosig
Jun 16, 2012·Zeitschrift für Rheumatologie·M Janneck, C Iking-Konert
Jun 16, 2012·Zeitschrift für Rheumatologie·J O SchröderM Both
Aug 30, 2012·Zeitschrift für Rheumatologie·T MagnusJ U Holle
Nov 10, 2012·Zeitschrift für Rheumatologie·J U HolleW L Gross
Apr 24, 2013·Zeitschrift für Rheumatologie·H Morbach, H J Girschick
Nov 7, 2013·Zeitschrift für Rheumatologie·I Kötter, J C Henes
Aug 8, 2013·Zeitschrift für Rheumatologie·M JanneckC Iking-Konert
Jun 8, 2013·Zeitschrift für Rheumatologie·J U Holle
May 17, 2011·Journal of Neurology·Jens WitschGeorge Trendelenburg
Oct 25, 2013·Journal of Neurology·Matthew Evans, Hadi Manji
Sep 21, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kjell Tullus, Stephen D Marks
Nov 6, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michal MalinaClaus Peter Schmitt
Dec 15, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Sanjeev BawejaLawrence P McMahon
Apr 28, 2011·Clinical Rheumatology·Frances ReesPeter Lanyon
Nov 1, 2011·Modern Rheumatology·Chethana Dharmapalaiah, Richard A Watts
Nov 30, 2011·Modern Rheumatology·Wataru FujiiYutaka Kawahito
Nov 2, 2011·Internal and Emergency Medicine·Mariagrazia CatanosoCarlo Salvarani
Oct 12, 2012·Current Allergy and Asthma Reports·Jennifer L RogersTeresa K Tarrant
Oct 29, 2013·Current Pain and Headache Reports·Noa SchwartzJohannes Nowatzky
Sep 30, 2010·Current Rheumatology Reports·Cees G M Kallenberg
Aug 25, 2011·Current Rheumatology Reports·Andy Abril
Jan 31, 2012·Current Rheumatology Reports·Marinka TwiltDavid Cabral
Aug 17, 2012·Current Rheumatology Reports·Duvuru Geetha, Philip Seo
Jul 28, 2013·Current Rheumatology Reports·Gabriela M EspinozaLevent Akduman
Jul 31, 2013·Current Rheumatology Reports·Teresa K Chen, Derek M Fine
Aug 21, 2013·Current Rheumatology Reports·Lindsay Lally, Robert F Spiera
Jan 25, 2012·Current Treatment Options in Cardiovascular Medicine·Carol A Langford
Mar 9, 2012·Current Treatment Options in Neurology·Marc Gotkine, Adi Vaknin-Dembinsky
Mar 12, 2013·Current Treatment Options in Neurology·Marc Gotkine, Adi Vaknin-Dembinsky
Feb 22, 2011·Clinical Reviews in Allergy & Immunology·Cees G M Kallenberg
Jun 7, 2012·Clinical Reviews in Allergy & Immunology·Cees G M Kallenberg
Dec 14, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Gloria von GeldernKyra Becker
Mar 20, 2013·Best Practice & Research. Clinical Rheumatology·Rosemary WallerRaashid Luqmani
Mar 20, 2013·Best Practice & Research. Clinical Rheumatology·Erin M Wilfong, Philip Seo
Mar 20, 2013·Best Practice & Research. Clinical Rheumatology·Gunnar Tomasson
Mar 20, 2013·Best Practice & Research. Clinical Rheumatology·Loïc Guillevin
Mar 14, 2013·The Journal of Laryngology and Otology·A K Ebrahim, J W Loock

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Related Papers

The New England Journal of Medicine
Rachel B JonesEuropean Vasculitis Study Group
The New England Journal of Medicine
C PagnouxFrench Vasculitis Study Group
The New England Journal of Medicine
Wegener's Granulomatosis Etanercept Trial (WGET) Research Group
© 2021 Meta ULC. All rights reserved