Rivaroxaban - Metabolism, Pharmacologic Properties and Drug Interactions

Current Drug Metabolism
Tomas KvasnickaJan Kvasnicka

Abstract

Rivaroxaban represents a selective direct inhibitor of activated coagulation factor X (FXa) having peroral bioavailability and prompt onset of action. The absorbtion of rivaroxaban is quick, reaching maximum plasma concentration 2-4 hours following its administration. Peroral bioavailability is high (80-100 %) and pharmacokinetic variability is considered to be moderate (coefficient of variation 30-40 %). This review discusses the properties, drug interactions, pharmacokinetics and clinical indications of rivaroxaban. Dosing regimen of rivaroxaban was derived from pharmacologic data of the development program aimed to gain strong antithrombotic drug and balance between efficacy and risk of bleeding in patients. Results of doseranging trials, pharmacokinetic models and randomised studies of phase III advocate the use of such schemes in everyday practice. The drug has been manufactured to fulfill clinical requirements in a variety of indications in adults: prophylaxis of venous thromboembolism (VTE) following elective knee or hip replacement surgical intervention, therapy and secondary prophylaxis of VTE, prophylaxis of ischemic stroke and embolism in individuals diagnosed with nonvalvular atrial fibrillation (NVAF) with risky ch...Continue Reading

Citations

Jul 19, 2019·Clinical Cardiology·Kaja AblefoniAndreas Bollmann
Jul 8, 2020·Pharmaceutical Biology·Jia ChongJiefu Yang
Dec 31, 2019·Journal of Diabetes Research·Dana PrídavkováMarián Mokáň
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