Rivaroxaban Versus Enoxaparin for Venous Thromboembolism Prophylaxis after Hip and Knee Arthroplasty

The Journal of Arthroplasty
Michael A ChartersCraig D Silverton

Abstract

The oral Factor Xa inhibitor rivaroxaban (Xarelto) has been the pharmacologic agent used for venous thromboembolism (VTE) prophylaxis after primary hip and knee arthroplasty (THA/TKA) at our institution since February 2012. The purpose of our study was to compare rates of VTE and major bleeding between rivaroxaban and our previous protocol of enoxaparin after THA/TKA. A retrospective cohort study was performed including 2406 consecutive patients at our institution between 1/1/11 and 9/30/13. Patients who did not have unilateral primary THA/TKA or who received other anticoagulants were excluded. Of the 1762 patients included, 1113 patients (63.2%) received enoxaparin and 649 patients (36.8%) received rivaroxaban. This study found no demonstrable differences between these two anticoagulants in rates of VTE, infection, reoperation, transfusion, or major bleeding. Therapeutic, Retrospective comparative study, Level III.

References

Jun 27, 2008·The New England Journal of Medicine·Bengt I ErikssonUNKNOWN RECORD1 Study Group
Jun 27, 2008·The New England Journal of Medicine·Michael R LassenUNKNOWN RECORD3 Investigators
May 2, 2009·The Journal of Bone and Joint Surgery. British Volume·B I ErikssonM R Lassen
Oct 31, 2012·The Journal of Bone and Joint Surgery. British Volume·M R LassenA G G Turpie

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Citations

May 14, 2016·Orthopedics·Nicholas FrischCraig D Silverton
Mar 21, 2017·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Dimitrios V PapadopoulosAnastasios V Korompilias
Apr 25, 2020·International Journal of Clinical Pharmacy·Sadhbh Ní CheallaighLaura J Sahm
Jan 23, 2016·The Journal of Bone and Joint Surgery. American Volume·Gwo-Chin Lee

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