PMID: 9555969Apr 29, 1998Paper

Rivastigmine, a brain-selective acetylcholinesterase inhibitor, ameliorates cognitive and motor deficits induced by closed-head injury in the mouse

Journal of Neurotrauma
Y ChenM Weinstock

Abstract

The effects of Rivastigmine, a novel centrally-acting anticholinesterase agent, were evaluated on cerebral edema, neurological and motor deficits, and impairment of spatial memory induced in mice by closed-head injury (CHI). Severe injury was induced in the left hemisphere of mice under ether anesthesia. Rivastigmine (1 or 2 mg/kg) or saline (10 ml/kg) was injected SC 5 min later. Rivastigmine (2 mg/kg) reduced cerebral edema by at least 50% (p < 0.01), 24 h after CHI and accelerated the recovery of motor function 7 and 14 days after CHI. Control mice (n = 24), previously trained to find the goal platform in a Morris water maze failed to recall or relearn its position for at least 11 days post-injury. Those given a single injection of Rivastigmine (2 mg/kg) regained their pre-test latencies by the third day after CHI. The neuroprotective effects of Rivastigmine on brain edema, neurological and motor function, and performance in the Morris water maze were completely antagonized by simultaneous SC injection of either scopolamine (0.5 mg/kg) or mecamylamine (2.5 mg/kg). The antagonists alone had no significant effect on any of these parameters. These data show that the reduction by Rivastigmine of the immediate and long-term seque...Continue Reading

References

Dec 1, 1975·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·D N Brooks
Jan 1, 1990·Neurobiology of Aging·O J VogelsB P Schulte
Sep 1, 1987·Behavioral and Neural Biology·E D LevinG D Ellison
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·O U Scremin, D J Jenden
Jan 1, 1967·Journal of Neuropathology and Experimental Neurology·I Klatzo
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T HirataR J Traystman
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S SadoshimaM Fujishima
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O U ScreminB P Imbimbo
Jun 1, 1996·Journal of Neurotrauma·R J HammB G Lyeth
Aug 1, 1996·Journal of Neurotrauma·L K GormanR J Traystman

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Citations

Sep 19, 2003·Current Psychiatry Reports·David B Arciniegas
Mar 20, 2002·Journal of Neurotrauma·Iain MurdochDeborah Dewar
Jul 27, 2011·Journal of Neurotrauma·Daniel P HolschneiderOscar U Scremin
Apr 3, 2001·Expert Opinion on Investigational Drugs·A I Maas
Feb 5, 2009·Brain Injury : [BI]·Jonathan M SilverDavid B Arciniegas
Sep 25, 2007·Brain Injury : [BI]·Cornelius Kurt DonatPeter Brust
Jun 24, 2008·Brain Injury : [BI]·Norman A Poole, Niruj Agrawal
Oct 14, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cornelius K DonatPeter Brust
Jun 27, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Paolo BaroneRoger M Lane
Feb 24, 2010·Journal of Clinical Pharmacy and Therapeutics·G K-C WongW S Poon
Sep 3, 2004·Neuroscience and Biobehavioral Reviews·Scott T FujimotoTracy K McIntosh
Mar 20, 2004·Physical Medicine and Rehabilitation Clinics of North America·David B Arciniegas, Jeannie L Topkoff
Nov 15, 2011·Neuroscience Letters·Manojkumar ValiyaveettilMadhusoodana P Nambiar
Mar 10, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Roger M Lane, Yunsheng He
Nov 20, 2012·Chemico-biological Interactions·Manojkumar ValiyaveettilMadhusoodana P Nambiar
Feb 7, 2006·Experimental Gerontology·Eitan MoorRon Kohen
Feb 15, 2000·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·D GoldblumM Böhnke
Dec 2, 2000·Journal of Neurotrauma·V ElangovanE Shohami
Oct 24, 2002·The Journal of ECT·Mathias ZinkFritz A Henn
Oct 4, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Merav Yogev-FalachMoussa B H Youdim
Sep 19, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Merav Yogev-FalachMoussa B H Youdim
Aug 9, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M V ChelyapinaO S Zaytsev
Mar 17, 2018·Neuroscience and Biobehavioral Reviews·Laura B TuckerJoseph T McCabe

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Brain Injury & Trauma

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