Rivastigmine as a modulator of the neuronal glutamate transporter rEAAC1 mRNA expression

Dementia and Geriatric Cognitive Disorders
Josefine AndinJan Marcusson

Abstract

Alzheimer's disease is a neurodegenerative disorder that affects the cholinergic, glutamatergic and monoaminergic systems in the neocortex and hippocampus. Today, the major pharmacological treatment involves the use of acetylcholinesterase inhibitors (AChEIs). In this study, an in situ hybridisation technique (using digoxigenin-labelled cRNA probes) was used to elucidate changes in mRNA expression of the neuronal glutamate transporter, rat excitatory amino carrier 1 (rEAAC1), after treatment with the AChEI rivastigmine. Compared with saline-treated rats, the rats subchronically (3 days) and chronically (21 days), but not acutely, treated with rivastigmine showed a significant increase in rEAAC1 mRNA expression in the hippocampal areas cornu anterior 1 (CA1), CA2, CA3 and dentate gyrus (p < 0.01), but not in the cortical areas. These results provide the first evidence that the glutamatergic system is modulated following acetylcholinesterase inhibition by rivastigmine, a finding, which is likely to be of importance for the clinical effects.

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Citations

Nov 30, 2007·Clinical Interventions in Aging·Maria Luisa OnorEugenio Aguglia
Mar 10, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Roger M Lane, Yunsheng He
Sep 16, 2005·Expert Review of Neurotherapeutics·Abhilash K Desai, George T Grossberg
Jun 2, 2012·Cephalalgia : an International Journal of Headache·Gianluca CoppolaJean Schoenen
Sep 28, 2018·CNS Drugs·Kevin P JensenMehmet Sofuoglu
Jan 11, 2008·Neurochemical Research·V N VyjayantiKalluri Subba Rao

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