Rivastigmine in moderately severe-to-severe Alzheimer's disease: Severe Impairment Battery factor analysis

Alzheimer's Research & Therapy
Steven FerrisXiangyi Meng

Abstract

The Severe Impairment Battery (SIB) is validated for assessing cognition in patients with severe dementia. The current analysis aimed to further investigate the cognitive efficacy of rivastigmine capsules, as assessed by SIB factor scores, in patients with moderately severe-to-severe Alzheimer's disease (AD). This was a retrospective analysis of a 26-week, multicenter, randomized, double-blind, placebo-controlled study of oral rivastigmine conducted in Spain. Previously reported outcome measures included the full SIB. Current analyses examined calculated scores and effect sizes for the change from baseline at Week 26 on: newly defined SIB subscales (derived by a factor analysis of the 40 SIB items, using the PROC FACTOR function (SAS)); previously defined memory, language and praxis subscales (derived by previous analysis of the nine SIB domains); and the individual SIB items. Treatment differences were assessed. SIB data were provided by 104 rivastigmine-treated patients and 106 patients receiving placebo (Intent-To-Treat Last Observation Carried Forward population). Significantly less decline was observed on the previously defined memory and language subscales, and the newly defined working memory/memory subscale in rivastigm...Continue Reading

References

Jul 30, 1982·Science·R T BartusA S Lippa
Aug 22, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·P Murali DoraiswamyJeffrey Veach
Mar 18, 2004·International Journal of Geriatric Psychiatry·A BurnsP Quarg
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Nov 30, 2006·Alzheimer Disease and Associated Disorders·Frederick A SchmittUNKNOWN Memantine MEM-MD-02 Study Group

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Citations

Dec 3, 2014·The Veterinary Clinics of North America. Small Animal Practice·Charles H Vite, Elizabeth Head
Sep 16, 2015·American Journal of Alzheimer's Disease and Other Dementias·Richard S IsaacsonXiangyi Meng
Jul 10, 2018·Dementia and Geriatric Cognitive Disorders Extra·Hiroyuki TanakaTakashi Nishikawa
Dec 12, 2020·Genetics and Molecular Biology·Patricia Fernanda Rocha-DiasRicardo Lehtonen Rodrigues Souza

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Clinical Trials Mentioned

NCT00948766

Software Mentioned

MedAvante
SAS
Accera

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