RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Jessie M SutherlandEileen A McLaughlin

Abstract

Controlled gene regulation during gamete development is vital for maintaining reproductive potential. During the process of gamete development, male germ cells experience extended periods of inactive transcription despite requirements for continued growth and differentiation. Spermatogenesis therefore provides an ideal model to study the effects of posttranscriptional control on gene regulation. During spermatogenesis posttranscriptional regulation is orchestrated by abundantly expressed RNA-binding proteins. One such group of RNA-binding proteins is the Musashi family, previously identified as a critical regulator of testis germ cell development and meiosis in Drosophila and also shown to be vital to sperm development and reproductive potential in the mouse. We focus in depth on the role and function of the vertebrate Musashi ortholog Musashi-1 (MSI1). Through detailed expression studies and utilizing our novel transgenic Msi1 testis-specific overexpression model, we have identified 2 unique RNA-binding targets of MSI1 in spermatogonia, Msi2 and Erh, and have demonstrated a role for MSI1 in translational regulation. We have also provided evidence to suggest that nuclear import protein, IPO5, facilitates the nuclear translocati...Continue Reading

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Citations

Sep 25, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Bettina P MihalasJanet E Holt
Jul 29, 2016·World Journal of Microbiology & Biotechnology·Barış Gökalsın, Nüzhet Cenk Sesal
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Sep 9, 2017·Journal of Cellular Physiology·Jessie M SutherlandEileen A McLaughlin
May 7, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Dilshan H BeligalaMichael E Geusz
Apr 18, 2019·Journal of Cell Science·Menno SpitsJacques Neefjes
May 26, 2020·Stem Cell Research & Therapy·Mahboobeh ForouzanfarKamran Ghaedi
Feb 2, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander E KudinovYanis Boumber
Mar 26, 2021·OncoTargets and Therapy·Jian SunMing Dong
Apr 30, 2021·Journal of Cell Science·Joanna KalitaRoderick Y H Lim
Jul 27, 2021·Andrologia·Zohreh Talebi-YazdabadiMohammad Hossein Nasr-Esfahani
Aug 25, 2021·Seminars in Cell & Developmental Biology·Benedict NathanielKate L Loveland

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