RNA binding proteins implicated in Xist-mediated chromosome silencing

Seminars in Cell & Developmental Biology
Benoit Moindrot, Neil Brockdorff

Abstract

Chromosome silencing by Xist RNA occurs in two steps; localisation in cis within the nuclear matrix to form a domain that corresponds to the territory of the inactive X chromosome elect, and transduction of silencing signals from Xist RNA to the underlying chromatin. Key factors that mediate these processes have been identified in a series of recent studies that harnessed comprehensive proteomic or genetic screening strategies. In this review we discuss these findings in light of prior knowledge both of Xist-mediated silencing and known functions/properties of the novel factors.

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Citations

Jul 20, 2016·Seminars in Cell & Developmental Biology·Andrea Cerase
Apr 28, 2018·Human Molecular Genetics·Bradley P BalatonCarolyn J Brown
Nov 28, 2018·Journal of Biomedical Materials Research. Part a·Fei XuHong Zheng
Sep 28, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Zhipeng LuHoward Y Chang
Jul 25, 2019·Journal of Molecular Cell Biology·Alisha N Jones, Michael Sattler
Mar 16, 2019·BMC Genomics·Kerem Wainer Katsir, Michal Linial
Jun 9, 2020·Nucleic Acids Research·Marisa MüllerPeter B Becker
Jan 5, 2020·Development·Catherine PatratClaire Rougeulle
Jun 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Xiaofeng FangCaroline Dean
Sep 27, 2019·Frontiers in Cell and Developmental Biology·Barbara R Migeon
Feb 9, 2020·International Journal of Molecular Sciences·Marek KazimierczykJan Wrzesinski
May 8, 2018·Oncotarget·John Lalith Charles Richard, Pieter Johan Adam Eichhorn
Mar 21, 2020·Cellular and Molecular Life Sciences : CMLS·Botros B ShenodaSeena K Ajit
Aug 10, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Yi Lin, Xiaofeng Fang
Aug 28, 2021·Cells·Paola RebuzziniSilvia Garagna

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