RNA-dependent regulation of the cell wall stress response.

Nucleic Acids Research
Mathieu CatalaSherif Abou Elela

Abstract

Stress response requires the precise modulation of gene expression in response to changes in growth conditions. This report demonstrates that selective nuclear mRNA degradation is required for both the cell wall stress response and the regulation of the cell wall integrity checkpoint. More specifically, the deletion of the yeast nuclear dsRNA-specific ribonuclease III (Rnt1p) increased the expression of the mRNAs associated with both the morphogenesis checkpoint and the cell wall integrity pathway, leading to an attenuation of the stress response. The over-expression of selected Rnt1p substrates, including the stress associated morphogenesis protein kinase Hsl1p, in wild-type cells mimicked the effect of RNT1 deletion on cell wall integrity, and their mRNAs were directly cleaved by the recombinant enzyme in vitro. The data supports a model for gene regulation in which nuclear mRNA degradation optimizes the cell response to stress and links it to the cell cycle.

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Citations

Aug 2, 2013·International Journal of Molecular Sciences·María Teresa Martínez-PastorSergi Puig
Sep 15, 2015·FEBS Letters·Vikash SinghRaghuvir S Tomar
Jun 4, 2016·Nucleic Acids Research·Marc-Andre ComeauSherif Abou Elela
Jan 10, 2019·FEMS Yeast Research·Cullen HorstmannKyoungtae Kim
Jan 30, 2020·Critical Reviews in Microbiology·Ana NovačićIgor Stuparević
Jun 27, 2019·Communications Biology·Mathieu Catala, Sherif Abou Elela
Dec 15, 2018·Wiley Interdisciplinary Reviews. RNA·Sherif Abou Elela, Xinhua Ji
Jan 12, 2020·Communications Biology·Mathieu Catala, Sherif Abou Elela

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Methods Mentioned

BETA
dissection
PCR
flow cytometry
light
light microscopy

Software Mentioned

Affymetrix
Columbus

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