PMID: 9175473May 1, 1997Paper

RNA editing and hypermutation by adenosine deamination

Trends in Biochemical Sciences
Brenda L Bass

Abstract

Double-stranded RNA adenosine deaminase (dsRAD) was discovered ten years ago. In the intervening decade, research on dsRAD has progressed not only predictably, such as with the purification of the enzyme and identification of cDNAs, but also in some quite surprising ways. This review covers both areas of progress, but will concentrate on the surprises, which include the discovery that dsRAD is a member of a larger family of deaminases and the identification of RNAs that appear to be targets for these deaminases in vivo.

Citations

Aug 17, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Maas, A Rich
Dec 9, 1998·Journal of Biomedical Science·J LiouC Chang
Jan 25, 2012·Molecular Biotechnology·Wei TangMichael Page
Jan 28, 2004·Comptes rendus biologies·Takahiro NagaseOsamu Ohara
Dec 20, 2000·Brain Research·H TanakaR S Zukin
Aug 23, 2002·Brain Research. Molecular Brain Research·Enbo MaGabriel G Haddad
Dec 22, 2000·Neurobiology of Aging·F W van LeeuwenE M Hol
Nov 30, 2002·Biochimie·Myriam Schaub, Walter Keller
Feb 12, 2000·Neuroscience· Paupard M-CR S Zukin
Dec 20, 2002·Journal of Structural Biology·Michael Doyle, Michael F Jantsch
Jun 18, 2003·Respiratory Physiology & Neurobiology·Reza Farahani, Gabriel G Haddad
May 19, 2011·Nature Communications·Julie M EggingtonBrenda L Bass
Nov 10, 2013·Nature Communications·Yiannis A SavvaRobert A Reenan
Jul 12, 2002·The EMBO Journal·Jeannette WolfWalter Keller
Aug 3, 2011·Human Molecular Genetics·Cailin E JoyceAnne M Bowcock
Dec 26, 2001·Nucleic Acids Research·Reiko KikunoOsamu Ohara
Feb 13, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Elisabetta UlluChristian Tschudi
Jul 23, 1999·Annals of the New York Academy of Sciences·A Herbert, A Rich
Oct 5, 2001·Clinical Microbiology Reviews·C E Samuel
Apr 29, 2005·Journal of Virology·Deborah R TaylorStephen M Feinstone
Jun 5, 2002·Annual Review of Biochemistry·Brenda L Bass
Apr 24, 2008·RNA·Eva M RiedmannMichael F Jantsch
Oct 27, 2011·PLoS Genetics·Shai CarmiErez Y Levanon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.