RNA editing in plant mitochondria.

Science
R HieselA Brennicke

Abstract

Comparative sequence analysis of genomic and complementary DNA clones from several mitochondrial genes in the higher plant Oenothera revealed nucleotide sequence divergences between the genomic and the messenger RNA-derived sequences. These sequence alterations could be most easily explained by specific post-transcriptional nucleotide modifications. Most of the nucleotide exchanges in coding regions lead to altered codons in the mRNA that specify amino acids better conserved in evolution than those encoded by the genomic DNA. Several instances show that the genomic arginine codon CGG is edited in the mRNA to the tryptophan codon TGG in amino acid positions that are highly conserved as tryptophan in the homologous proteins of other species. This editing suggests that the standard genetic code is used in plant mitochondria and resolves the frequent coincidence of CGG codons and tryptophan in different plant species. The apparently frequent and non-species-specific equivalency of CGG and TGG codons in particular suggests that RNA editing is a common feature of all higher plant mitochondria.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 1, 1986·Current Genetics·D B SternW F Thompson
Jan 1, 1980·Methods in Enzymology·A M Maxam, W Gilbert

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Citations

Nov 1, 1991·Plant Molecular Biology·G C Ward, C S Levings
Oct 1, 1996·Plant Molecular Biology·R M MaierJ M Grienenberger
Sep 1, 1991·Plant Molecular Biology·V MannJ Hirschberg
Apr 1, 1994·Molecular & General Genetics : MGG·B LippokB Wissinger
Mar 20, 1995·Molecular & General Genetics : MGG·G V BörnerC Schmelzer
Jan 20, 1995·Molecular & General Genetics : MGG·W Jekabsons, W Schuster
Nov 1, 1991·Current Genetics·W SchusterA Brennicke
Jul 1, 1990·Current Genetics·J L MacfarlaneD R Wolstenholme
Dec 1, 1991·Current Genetics·R A SalazarF Kempken
Mar 1, 1991·Current Genetics·K D Pruitt, M R Hanson
Oct 1, 1993·Current Genetics·P BrandtA Brennicke
Jun 28, 2011·Current Genetics·Dominique BéguAlejandro Araya
Feb 25, 2005·Molecular Genetics and Genomics : MGG·Matthias StaudingerFrank Kempken
Jul 25, 2006·Molecular Genetics and Genomics : MGG·Jeffrey P Mower, Jeffrey D Palmer
Dec 18, 2004·Plant Molecular Biology·A Harvey MillarHans-Peter Braun
Jul 17, 1996·Biochimica Et Biophysica Acta·G L Sper-WhitisJ C Vaughn

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