RNA, Genome Output and Input.

Frontiers in Genetics
Jörg MorfPaulo P Amaral

Abstract

RNA, the transcriptional output of genomes, not only templates protein synthesis or directly engages in catalytic functions, but can feed back to the genome and serve as regulatory input for gene expression. Transcripts affecting the RNA abundance of other genes act by mechanisms similar to and in concert with protein factors that control transcription. Through recruitment or blocking of activating and silencing complexes to specific genomic loci, RNA and protein factors can favor transcription or lower the local gene expression potential. Most regulatory proteins enter nuclei from all directions to start the search for increased affinity to specific DNA sequences or to other proteins nearby genuine gene targets. In contrast, RNAs emerge from spatial point sources within nuclei, their encoding genes. A transcriptional burst can result in the local appearance of multiple nascent RNA copies at once, in turn increasing local nucleic acid density and RNA motif abundance before diffusion into the nuclear neighborhood. The confined initial localization of regulatory RNAs causing accumulation of protein co-factors raises the intriguing possibility that target specificity of non-coding, and probably coding, RNAs is achieved through gen...Continue Reading

References

Oct 5, 2002·Nucleic Acids Research·Laura A Cassiday, L James Maher
Oct 20, 2006·PLoS Biology·Arjun RajSanjay Tyagi
Oct 6, 2007·Journal of Human Genetics·Kazuhiro MurakamiHiroyuki Kugoh
Feb 27, 2008·Molecular and Cellular Biology·Faizaan MohammadChandrasekhar Kanduri
Jun 20, 2008·Genome Research·Marcel E DingerJohn S Mattick
Jan 1, 2009·Genome Research·Jeremy R SanfordYunlong Liu
Jan 23, 2009·Nature Cell Biology·Miki EbisuyaEisuke Nishida
Oct 27, 2009·Nucleic Acids Research·Ron MiloMichael Springer
Sep 14, 2010·Developmental Cell·Yuko HasegawaShinichi Nakagawa
Oct 5, 2010·Cell·Ulf Andersson ØromRamin Shiekhattar
Dec 21, 2010·Nature Cell Biology·Yuntao S MaoDavid L Spector
Jan 18, 2011·Nature Cell Biology·Sergey P Shevtsov, Miroslav Dundr
Aug 6, 2011·Nucleus·Danièle Hernandez-Verdun
Jul 31, 2012·PLoS Genetics·Claudia KutterAna C Marques
Aug 3, 2012·Molecular Biology of the Cell·Vidisha TripathiKannanganattu V Prasanth
Oct 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Roy D DarLeor S Weinberger
Nov 8, 2012·Nature Structural & Molecular Biology·Sònia Guil, Manel Esteller
Jul 6, 2013·Cell·Igor Ulitsky, David P Bartel
Feb 5, 2014·Cold Spring Harbor Perspectives in Biology·Denise P Barlow, Marisa S Bartolomei
May 6, 2014·Current Biology : CB·Nimish KhannaAndrew S Belmont
Oct 2, 2014·Nature Reviews. Molecular Cell Biology·William H Hudson, Eric A Ortlund
Oct 31, 2015·Science·Alla A SigovaRichard A Young
May 27, 2016·Scientific Reports·Charles C BellAndrew C Perkins
Jul 28, 2016·Nature Communications·Katjana TantaleEdouard Bertrand
Oct 25, 2016·Cell Chemical Biology·Yue LiHiroshi Sugiyama
Oct 30, 2016·Trends in Genetics : TIG·Frédéric Chédin

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Methods Mentioned

BETA
electron microscopy
RNA-seq

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