RNA interference in embryonic stem cells and the prospects for future therapies

Gene Therapy
A HeidersbachM Ramalho-Santos

Abstract

In 1998, two distinct and exciting scientific fields emerged which have profoundly shaped the current direction of biomedical research. The discovery of RNA interference (RNAi) and the derivation of human embryonic stem (ES) cells have yielded exciting new possibilities for researchers and clinicians alike. While fundamentally different, aspects from these two fields may be combined to yield extraordinary scientific and medical benefits. Here, we review the prospects of combining RNAi and ES cell manipulation for both basic research and future therapies, as well as current limitations and obstacles that need to be overcome.

References

Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B H KollerO Smithies
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R Martin
Nov 6, 1998·Nature·L Timmons, A Fire
Nov 6, 1998·Science·J A ThomsonJ M Jones
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·M J ShamblottJ D Gearhart
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·M Kumar, G G Carmichael
Feb 3, 2000·Nature Cell Biology·F Wianny, M Zernicka-Goetz
Oct 27, 2001·Science·M Lagos-QuintanaT Tuschl
Oct 27, 2001·Science·R C Lee, V Ambros
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·E BillyW Filipowicz
Aug 15, 2002·Cell·Hynek WichterleThomas M Jessell
Sep 14, 2002·Science·Miguel Ramalho-SantosDouglas A Melton
Oct 17, 2002·Genes & Development·Lynn A HannaPatricia A Labosky
Nov 12, 2002·Nature Biotechnology·Ren-He XuJames A Thomson
Nov 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yuichi HoriSeung K Kim
Jan 7, 2003·Genes & Development·Ariel A AvilionRobin Lovell-Badge
Mar 22, 2003·RNA·Sheila A StewartCarl D Novina
May 20, 2003·Nature Biotechnology·Aimee L JacksonPeter S Linsley
Jun 11, 2003·Nature Genetics·Alan J BridgeRichard Iggo

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Citations

Mar 14, 2007·Stem Cells and Development·Cory R NicholasAndrew D Leavitt
Nov 21, 2007·Hematology·Dirk Grimm, Mark A Kay
Jul 21, 2009·Blood·Steven P Treon
Jul 1, 2010·Cytotherapy·Josep GamezInmaculada Bori-Fortuny
Oct 17, 2009·Biochemical and Biophysical Research Communications·Fatemeh Behnam Rassouli, Maryam M Matin
Jun 19, 2015·Biomaterials·Xiao HuangNorbert O Reich
Dec 25, 2012·Journal of the American Chemical Society·Bahareh ShirinfarKwang S Kim
Jun 23, 2006·Journal of Cellular Physiology·Baohong ZhangTodd A Anderson
Jun 26, 2009·Molecular Pharmaceutics·Chee Guan KohL James Lee

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