RNA interference in glial cells for nerve injury treatment

Journal of Tissue Engineering
Junquan LinSing Yian Chew

Abstract

Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed.

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Citations

May 8, 2021·Journal of Biomedical Materials Research. Part a·Zalike Keskin-ErdoganJonathan C Knowles

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Methods Mentioned

BETA
antisense oligonucleotides
transfection
gene knockdown
antisense oligonucleotide
transfect
transmission electron microscopy

Clinical Trials Mentioned

NCT00876863
NCT00985517
NCT00004080
NCT00004041

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