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RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines

Cancer Gene Therapy

Jan 22, 2003

D P CiocaK Kiyosawa

Abstract

RNA interference (RNAi) is a cellular pathway of gene silencing in a sequence-specific manner at the messenger RNA level. The basic mechanism behind RNAi is the breaking of a double-stranded RNA (dsRNA) matching a specific gene sequence into short pieces called short interfering RNA, wh...read more

Mentioned in this Paper

Biochemical Pathway
Gene Expression Regulation, Neoplastic
Antineoplastic Agents
Transfection
Raf-1 Protein
RNA, Small Interfering
Etoposide
Cosuppression
RNA, Double-Stranded
Proto-Oncogene Proteins c-raf
35
1
Paper Details
References
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  • Citations65
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  • References31
  • Citations65
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RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines

Cancer Gene Therapy

Jan 22, 2003

D P CiocaK Kiyosawa

PMID: 12536201

DOI: 10.1038/sj.cgt.7700544

Abstract

RNA interference (RNAi) is a cellular pathway of gene silencing in a sequence-specific manner at the messenger RNA level. The basic mechanism behind RNAi is the breaking of a double-stranded RNA (dsRNA) matching a specific gene sequence into short pieces called short interfering RNA, wh...read more

Mentioned in this Paper

Biochemical Pathway
Gene Expression Regulation, Neoplastic
Antineoplastic Agents
Transfection
Raf-1 Protein
RNA, Small Interfering
Etoposide
Cosuppression
RNA, Double-Stranded
Proto-Oncogene Proteins c-raf
35
1

Similar Papers Found In These Feeds

Signal Transduction & Control of Gene Expression

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society

Investigating siRNA delivery to chronic myeloid leukemia K562 cells with lipophilic polymers for therapeutic BCR-ABL down-regulation

Journal of Controlled Release : Official Journal of the Controlled Release SocietyJune 4, 2013
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Paper Details
References
  • References31
  • Citations65
1234
  • References31
  • Citations65
12345...
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