RNA interference: potential therapeutic targets

Applied Microbiology and Biotechnology
S JanaJ K Deb

Abstract

One of the most exciting findings in recent years has been the discovery of RNA interference (RNAi). RNAi methodologies hold the promise to selectively inhibit gene expression in mammals. RNAi is an innate cellular process activated when a double-stranded RNA (dsRNA) molecule of greater than 19 duplex nucleotides enters the cell, causing the degradation of not only the invading dsRNA molecule, but also single-stranded (ssRNAs) RNAs of identical sequences, including endogenous mRNAs. The use of RNAi for genetic-based therapies has been widely studied, especially in viral infections, cancers, and inherited genetic disorders. As such, RNAi technology is a potentially useful method to develop highly specific dsRNA-based gene-silencing therapeutics.

References

Sep 19, 1997·Oncogene·K KoeraM Katsuki
Dec 5, 1998·Science·H TabaraC C Mello
Feb 3, 2000·Nature Cell Biology·F Wianny, M Zernicka-Goetz
Aug 10, 2000·Nature Biotechnology·J R Kennerdell, R W Carthew
Feb 7, 2001·Genes & Development·S M ElbashirT Tuschl
Mar 10, 2001·Apoptosis : an International Journal on Programmed Cell Death·J Gil, M Esteban
Mar 10, 2001·Genes & Development·P A Sharp
May 25, 2001·Nature·B L Bass
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·N J CaplenR A Morgan
Oct 27, 2001·Science·R C Lee, V Ambros
Dec 6, 2001·Current Drug Targets·M Johnson-Saliba, D A Jans
Jan 26, 2002·Human Molecular Genetics·Natasha J CaplenRichard A Morgan
Jan 30, 2002·Trends in Biotechnology·Natasha J Caplen
Feb 9, 2002·Science·William M WinstonCraig P Hunter
Mar 15, 2002·Current Opinion in Genetics & Development·György Hutvágner, Phillip D Zamore
Mar 23, 2002·Science·Thijn R BrummelkampReuven Agami
Apr 18, 2002·Genes & Development·Patrick J PaddisonDouglas S Conklin
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Guangchao SuiYang Shi
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jenn-Yah YuDavid L Turner
May 15, 2002·Current Biology : CB·Mariana Lagos-QuintanaThomas Tuschl
Jun 4, 2002·Nature Medicine·Carl D NovinaPhillip A Sharp
Jun 28, 2002·Nature·Jean-Marc JacqueMario Stevenson
Jul 5, 2002·Nature·Anton P McCaffreyMark A Kay

❮ Previous
Next ❯

Citations

Aug 16, 2011·Biomacromolecules·Nghia P TruongMichael J Monteiro
Jan 1, 2009·Molecular Pharmaceutics·Kun Gao, Leaf Huang
Apr 5, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shyh-Dar LiLeaf Huang
Jul 15, 2006·Nature Biotechnology·Gary Walsh
Oct 10, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shyh-Dar LiLeaf Huang
Jun 21, 2008·Clinical and Experimental Pharmacology & Physiology·Paul J White
Jul 2, 2011·Nanomedicine·Surendra NimeshRamesh Chandra
Sep 22, 2012·Journal of Drug Targeting·Shubiao ZhangLeaf Huang
Aug 10, 2010·Journal of Virological Methods·Jiangnan LiChangchun Tu
Jul 16, 2008·International Journal of Pharmaceutics·Elias Fattal, Amélie Bochot
Aug 25, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shubiao ZhangBaichao Ma
Sep 11, 2018·Expert Opinion on Drug Delivery·Ikramy A KhalilHideyoshi Harashima
Nov 6, 2009·Macromolecular Bioscience·Jie ChenXuesi Chen
Nov 17, 2009·Plastic and Reconstructive Surgery·Ashim K GuptaArun K Gosain
Mar 3, 2017·Topics in Current Chemistry·Myung Sook HuhKwangmeyung Kim
Sep 21, 2011·Bioorganic Chemistry·Shubiao ZhangShufen Zhang
Jun 6, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mohammad Mahfuz Ali Khan ShawanChiranjib Chakraborty

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.