RNA-loaded dendritic cells: more than a tour de force in cancer therapeutics

Immunotherapy
Aishwarya JoshiRajeev K Tyagi

Abstract

A wide array of therapeutic strategies has been implemented against cancers, yet their clinical benefit is limited. The lack of clinical efficacy of the conventional treatment options might be due to the inept immune competency of the patients. Dendritic cells (DCs) have a vital role in initiating and directing immune responses and have been frequently used as delivery vehicles in clinical research. The recent clinical data suggest the potential use of DCs pulsed with nucleic acid, especially with RNA holds a great potential as an immunotherapeutic measure with compare to other cancer therapeutics. This review mainly deals with the DCs and their role in transfection with RNA in cancer immunotherapy.

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Methods Mentioned

BETA
transfection
transfect

Clinical Trials Mentioned

NCT02528682
NCT02405338
NCT02465268
NCT02529072
NCT02649582
NCT02808364
NCT02709616
NCT01326104
NCT03334305
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