May 20, 1998

RNA-mediated signaling in transcription

Nature Structural Biology
M A Weiss

Abstract

Structures of phage transcriptional antitermination complexes define novel motifs for recognition of RNA hairpins by arginine-rich peptides. A bent alpha-helix in each case follows the contour of an induced GNRA-like fold. A phage-specific pattern of base pairing, base stacking and base flipping underlies biological specificity and permits engagement with RNA polymerase. The structures suggest a mechanism of RNA-mediated signaling in transcriptional regulation.

  • References52
  • Citations3

Citations

Mentioned in this Paper

RNA Polymerase II
Transcriptional Regulation
Molecular Helix
DNA-Directed RNA Polymerase
RNA Polymerase Assembly Pathway
Complex (molecular entity)
Transcription, Genetic
Bacteriophages
Bacteriophage P22
Helix (Snails)

About this Paper

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.