RNA molecules as anti-cancer agents

Seminars in Cancer Biology
Inbar FriedrichAlexander Levitzki

Abstract

The inhibition of cancer growth and progression is one of the major challenges facing modern medicine. Despite significant progress in the development of therapies against cancer, only in a few cases are these therapies effective. Because cancer is a complex disease, agents that target a single oncogenic pathway have low efficacy, in addition to allowing the emergence of drug resistance. There is a need for specific therapy, which can affect a broad range of cancers, with minimal side effects. Here we summarize several novel anti-cancer strategies that answer the above criteria. These strategies utilize the multiple anti-proliferative effects of double stranded RNA (dsRNA): (1) the classical antisense RNA hybridizes with its target mRNA, leading to reduced levels of a specific oncoprotein; (2) short dsRNA of specific sequence, known as small inhibitory RNA (siRNA), can selectively and efficiently inhibit expression of specific oncogenes, expressed in cancer cells but not in normal cells. Shutting down the expression of cancer-promoting genes by siRNA has proven to be an effective approach against several cancers; (3) long dsRNA, frequently expressed in cells infected with viruses, activates mechanisms that efficiently kill the ...Continue Reading

Citations

Jul 24, 2012·Advanced Drug Delivery Reviews·Danijela Koppers-LalicD Michiel Pegtel
Jan 25, 2006·Journal of Nanoscience and Nanotechnology·Peixuan Guo
Mar 30, 2011·BMC Cancer·B Leticia RodriguezZhengrong Cui
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