Abstract
The inhibition of cancer growth and progression is one of the major challenges facing modern medicine. Despite significant progress in the development of therapies against cancer, only in a few cases are these therapies effective. Because cancer is a complex disease, agents that target a single oncogenic pathway have low efficacy, in addition to allowing the emergence of drug resistance. There is a need for specific therapy, which can affect a broad range of cancers, with minimal side effects. Here we summarize several novel anti-cancer strategies that answer the above criteria. These strategies utilize the multiple anti-proliferative effects of double stranded RNA (dsRNA): (1) the classical antisense RNA hybridizes with its target mRNA, leading to reduced levels of a specific oncoprotein; (2) short dsRNA of specific sequence, known as small inhibitory RNA (siRNA), can selectively and efficiently inhibit expression of specific oncogenes, expressed in cancer cells but not in normal cells. Shutting down the expression of cancer-promoting genes by siRNA has proven to be an effective approach against several cancers; (3) long dsRNA, frequently expressed in cells infected with viruses, activates mechanisms that efficiently kill the ...Continue Reading
Citations
Feb 3, 2012·Nanomedicine·B Leticia RodriguezZhengrong Cui
Jul 24, 2012·Advanced Drug Delivery Reviews·Danijela Koppers-LalicD Michiel Pegtel
Jan 25, 2006·Journal of Nanoscience and Nanotechnology·Peixuan Guo
Mar 30, 2011·BMC Cancer·B Leticia RodriguezZhengrong Cui
Jul 14, 2011·Nucleic Acid Therapeutics·Chan Il ChangDong-ki Lee
Aug 12, 2009·International Journal of Colorectal Disease·Kamal YavariMohammad Hossein Babaei
Nov 22, 2005·Expert Opinion on Drug Delivery·Ram I MahatoRamareddy V Guntaka
May 20, 2015·Biomacromolecules·Jing ChenJianzhong Du
Jul 18, 2009·Archives of Medical Research·Kamal YavariMohammad Hosein Babaei
Nov 18, 2011·ISRN Oncology·Hong-Jun XiangKe-Feng Dou
Oct 18, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Helena Santos-Rosa, Carlos Caldas
Jan 13, 2006·Brain Research·Xiu-Huai LiuElliott Kagan
Oct 24, 2007·Cellular & Molecular Biology Letters·Si-Jin LiuGuo-Fa Hu
May 7, 2013·Molecular Pharmaceutics·B Leticia RodriguezZhengrong Cui
Dec 8, 2004·Oncogene·Qi-Wen Fan, William A Weiss
Oct 12, 2005·International Journal of Cancer. Journal International Du Cancer·Shuji AwanoBadar A Usmani
Apr 23, 2005·Cell Death and Differentiation·G N Barber
Oct 5, 2010·Endocrine Journal·Akira SugawaraSadayoshi Ito
Jun 16, 2005·Molecular Pharmacology·Laura GhisolfiAngelo Nicolin
Dec 28, 2018·Journal of Chromatographic Science·Wei ZhengYang Gao