RNA N-6-methyladenosine enzymes and resistance of cancer cells to chemotherapy and radiotherapy.

Epigenomics
Meiyi XiangDajun Deng

Abstract

Aim: As one of the early adaptive mechanisms by which cells respond to environmental changes, RNA modification appears to be a very promising target for cancer treatment. Results: RNA modifications are currently a hot topic in epigenetic research. Emerging experimental studies show that expression alterations of multiple m6A enzymes, including demethylase FTO, methyltransferase METTL3 and WTAP, mediate the development of resistance of cancer cells to various treatments. A set of small molecular chemical drugs targeted to these m6A enzymes are under development. Intervention of RNA m6A methylation is a possible therapeutic strategy to overcome drug resistance. Conclusions: RNA m6A methylation may play a crucial role in drug resistance development and intervention in cancer cells.

References

Oct 12, 2010·Advances in Genetics·Dajun DengYantao Du
Mar 2, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Hongwei TangDonghui Li
May 12, 2012·Nature·Dan DominissiniGideon Rechavi
Jan 29, 2013·Journal of Gastroenterology·Hong-Jae JoSae-Ock Oh
Dec 10, 2013·Nature Chemical Biology·Jianzhao LiuChuan He
Jan 15, 2014·Leukemia·H BansalS Bansal
Apr 10, 2014·Nature Reviews. Molecular Cell Biology·Kate D Meyer, Samie R Jaffrey
Sep 23, 2014·Nature Chemical Biology·Chao XuJinrong Min
Dec 3, 2014·Nucleic Acids Research·Yue HuangCai-Guang Yang
Dec 6, 2014·Cell Research·Moshe Shay Ben-HaimGideon Rechavi
Mar 25, 2015·Nature·Claudio R AlarcónSohail F Tavazoie
Jun 30, 2015·Nature Methods·Bastian LinderSamie R Jaffrey
Sep 1, 2015·Cell·Claudio R AlarcónSohail F Tavazoie
Oct 13, 2015·Journal of the American Chemical Society·Tianlu WangXiang Zhou
Nov 26, 2015·Cell·Kate D MeyerSamie R Jaffrey
Apr 28, 2016·Molecular Cell·Shuibin LinRichard I Gregory
Jan 21, 2017·Cell Research·Ang LiYun-Gui Yang
Jun 18, 2017·Cell·Ian A RoundtreeChuan He
Aug 2, 2017·Annual Review of Cell and Developmental Biology·Kate D Meyer, Samie R Jaffrey
Oct 14, 2017·Genes, Brain, and Behavior·M Engel, A Chen
Nov 7, 2017·Molecular Cell·Ryan A CootsShu-Bing Qian
Nov 25, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mengnuo ChenChun-Ming Wong

❮ Previous
Next ❯

Citations

Mar 17, 2021·British Journal of Cancer·Arumugam Paramasivam, Jayaseelan Vijayashree Priyadharsini
Jun 22, 2021·Frontiers in Pharmacology·Wen-Min ZhouJian-Ye Zhang
Aug 28, 2021·Journal of Experimental & Clinical Cancer Research : CR·Vera Miranda-GonçalvesCarmen Jerónimo
Nov 22, 2020·Seminars in Cancer Biology·Xiao HanYun-Gui Yang

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-seq

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Ting SunLiang Ming
Oxidative Medicine and Cellular Longevity
Jun ChenDing-Sheng Jiang
Journal of Hematology & Oncology
Yutian PanYongqian Shu
© 2022 Meta ULC. All rights reserved