RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing.

Genetics Research International
Manuel de la MataA R Kornblihtt

Abstract

The elongation phase of transcription lies at the core of several simultaneous and coupled events leading to alternative splicing regulation. Although underestimated in the past, it is at this phase of the transcription cycle where complexes affecting the transcription machinery itself, chromatin structure, posttranscriptional gene regulation and pre-mRNA processing converge to regulate each other or simply to consolidate higher-order complexes and functions. This paper focuses on the multiple processes that take place during transcription elongation which ultimately regulate the outcome of alternative splicing decisions.

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Citations

Nov 23, 2012·Nucleic Acids Research·Ales BalikIngo H Greger
Jan 18, 2013·PloS One·Hadas Keren-ShaulGil Ast
Nov 28, 2012·Wiley Interdisciplinary Reviews. RNA·Tina Lenasi, Matjaz Barboric
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Mar 25, 2014·Seminars in Cell & Developmental Biology·Minna-Liisa Änkö
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Jul 9, 2020·Journal of Clinical Medicine·Paula Martínez-RománVerónica Briz
Mar 6, 2021·Gene·Kiran Kumar Kolathur
Dec 19, 2017·Chemical Reviews·Xavier RamboutLynne E Maquat

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Methods Mentioned

BETA
acetylation
histone acetylation

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