RNA polymerase: structural determinant of the chromatin loop and the chromosome

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Peter R Cook

Abstract

Current models for RNA synthesis involve an RNA polymerase that tracks along a static template. However, research on chromatin loops suggests that the template slides past a stationary polymerase; individual polymerases tie the chromatin fibre into loops and clusters of polymerases determine the basic structure of the interphase and metaphase chromosome. RNA polymerase is then both a player and a manager of the chromosome loop.

References

Mar 1, 1990·The Journal of Cell Biology·D C HeS Penman
Nov 1, 1989·Molecular and Cellular Biology·D I ChasmanR D Kornberg
Nov 3, 1989·Science·R A LaskeyJ J Blow
Nov 20, 1989·European Journal of Biochemistry·P R Cook
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L F Liu, J C Wang
Mar 1, 1986·Molecular and Cellular Biology·M Emerman, H M Temin
Nov 14, 1972·Journal of Molecular Biology·A Worcel, E Burgi
Jan 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·O G Stonington, D E Pettijohn
Jan 1, 1984·Journal of Cell Science. Supplement·D A JacksonP R Cook
Aug 6, 1981·Nature·D A JacksonP R Cook
Jan 1, 1984·Journal of Cell Science. Supplement·O L Miller
Apr 1, 1984·The Journal of Cell Biology·K AnderssonB Daneholt
May 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J M Craig, W A Bickmore
Jan 1, 1993·Annual Review of Biochemistry·R C Conaway, J W Conaway
May 1, 1993·The Journal of Cell Biology·Z ZacharP M Bingham

❮ Previous
Next ❯

Citations

Aug 1, 1996·Journal of Cellular Biochemistry·J R Davie
Jul 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D A Jackson
Jun 26, 1998·Current Opinion in Cell Biology·P D Varga-Weisz, P B Becker
Oct 31, 2002·Journal of Structural Biology·Eva BártováMichael Hausmann
Apr 20, 2013·Chemical Reviews·Argyris Papantonis, Peter R Cook
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·J F Marko
Mar 1, 2012·Current Opinion in Genetics & Development·Lucas Brandon Edelman, Peter Fraser
Sep 2, 1998·Genomics·R Rizwana, P J Hahn
Jun 14, 2002·Biochimica Et Biophysica Acta·Stefan ErikssonGunnar Ahnström
Mar 29, 2000·Biophysical Journal·C G BaumannS M Block
Aug 29, 1997·Journal of Molecular Biology·Z Wang, P Dröge
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H W Chan
Dec 8, 1995·Science·H YinJ Gelles

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.