RNA-protein interactions in some small plant viruses

Journal of Biomolecular Structure & Dynamics
M G RossmannH S Savithri

Abstract

The structure of the three quasi-equivalent protein subunits A, B and C of the spherical, T = 3 southern bean mosaic virus (SBMV) have been carefully built in accordance with a refined electron density map of the complete virus. The lower electron density in the RNA portion of the map could not be explicitly interpreted in terms of a preferred RNA structure on which some icosahedral symmetry might have been imposed. However, the extremely basic nature of the interior surface of the coat protein must be associated with the binding and organization of the RNA. Comparison with the small spherical, T = 1 satellite tobacco necrosis virus (STNV; Liljas et al., J. Mol. Biol. 159, 93-108, 1982) and the T = 1 aggregate of alfalfa mosaic virus (AMV) protein (Fukuyama et al., J. Mol. Biol. 150, 33-41, 1981) showed similar results. The pattern of basic residues on the SBMV coat protein surface facing the RNA is able to dock a 9 base pair double-helical A-RNA structure with surprising accuracy. The basic residues are each associated with a different phosphate and the protein can make interactions with five bases in the minor groove. This may be one of a small number of ways in which the RNA interacts with SBMV coat protein. The self-assembl...Continue Reading

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Citations

Jan 1, 1989·Archives of Virology·H S SavithriM R Murthy
Aug 23, 2011·FEBS Letters·Allan OlspertErkki Truve
Dec 1, 2007·Journal of Molecular Biology·Katerina ToropovaNeil A Ranson
Apr 17, 2007·Journal of Molecular Biology·Peter G StockleyAlison E Ashcroft
Jul 26, 2018·Journal of Biomolecular Structure & Dynamics·V R Chechetkin, V V Lobzin

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