RNA recognition and translational regulation by a homeodomain protein

Nature
J Dubnau, G Struhl

Abstract

In Drosophila, the primary determinant of anterior pattern is the gradient morphogen bicoid (bcd), a homeodomain protein that binds DNA and transcriptionally activates target genes at different threshold concentrations. Here we present evidence that bcd also binds RNA and acts as a translational repressor to generate an opposing gradient of the homeodomain protein caudal (cad). RNA binding by bcd seems to involve direct interactions between the bcd homeodomain and discrete target sequences within the 3' untranslated region of the cad messenger RNA and to block the initiation of cad translation.

References

Jan 1, 1976·Progress in Nucleic Acid Research and Molecular Biology·S H Kim
Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·N C SeemanA Rich
Jul 3, 1992·Science·J D PuglisiJ R Williamson
Dec 20, 1991·Journal of Molecular Biology·M YarusE Christian
Jul 1, 1990·Molecular and Cellular Biology·D Munroe, A Jacobson
Nov 23, 1989·Nature·F MichelJ W Szostak
Jul 28, 1989·Cell·M Rebagliati
Oct 11, 1985·Nucleic Acids Research·J A Fischer, T Maniatis
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W E TheurkaufP C Wensink
Jul 1, 1988·Cell·W Driever, C Nüsslein-Volhard
Sep 24, 1983·Nucleic Acids Research·G M Rubin, A C Spradling
Jun 4, 1993·Cell·R TanA D Frankel
Sep 17, 1993·Science·K M Weeks, D M Crothers
Apr 21, 1995·Cell·D CurtisP D Zamore

❮ Previous
Next ❯

Citations

Nov 20, 1997·Journal of Cellular Physiology·D NiessingH Jäckle
Jun 10, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R W Williams
Jul 25, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L G KömüvesC Largman
Sep 5, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michel Vervoort
Dec 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E S ChestermanM J Kern
Oct 12, 2010·Cellular and Molecular Life Sciences : CMLS·Johannes Jaeger
Jan 25, 2008·Development Genes and Evolution·Michael StauberUrs Schmidt-Ott
Nov 1, 1996·Trends in Genetics : TIG·R Rivera-Pomar, H Jäckle
Dec 1, 1996·Trends in Cell Biology·R H Singer
Oct 1, 1996·The International Journal of Biochemistry & Cell Biology·R HovlandI F Pryme
Jan 22, 1998·Mutation Research·M B RogersL C Heller
Nov 15, 2000·Leukemia Research·P S JayaramanG Goodwin
Oct 17, 2001·Developmental and Comparative Immunology·D R Barreda, M Belosevic
Apr 24, 1999·Progress in Neurobiology·E Mohr
Aug 1, 1996·Current Opinion in Genetics & Development·P M Macdonald, C A Smibert
Oct 1, 1996·Current Opinion in Genetics & Development·G Seydoux
Jun 11, 2002·Methods : a Companion to Methods in Enzymology·Nancy D RodgersMegerditch Kiledjian
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·A W van der Velden, A A Thomas
Oct 23, 2003·Nature Reviews. Molecular Cell Biology·Alain Prochiantz, Alain Joliot
Jul 25, 2009·Nature Reviews. Molecular Cell Biology·Howard D Lipshitz
Nov 14, 1997·Nature Structural Biology·C Y ChienG T Montelione
Apr 16, 1999·The EMBO Journal·C H de Moor, J D Richter
Apr 11, 2000·Nucleic Acids Research·S E HarrisK J Johnson
Oct 5, 2002·Nucleic Acids Research·Laura A Cassiday, L James Maher
Jun 22, 2011·Cold Spring Harbor Perspectives in Biology·Joel D Richter, Paul Lasko
Oct 9, 2002·Genes & Development·Dierk NiessingHerbert Jäckle
Mar 24, 2004·The Plant Cell·Paul K BossCaroline Dean
Mar 21, 2009·Development, Growth & Differentiation·Sayaka SugiyamaTakao K Hensch
Jul 23, 1999·Annals of the New York Academy of Sciences·A Herbert, A Rich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.