RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome.

Proceedings of the National Academy of Sciences of the United States of America
Briana Van TreeckRoy Parker

Abstract

Stress granules are higher order assemblies of nontranslating mRNAs and proteins that form when translation initiation is inhibited. Stress granules are thought to form by protein-protein interactions of RNA-binding proteins. We demonstrate RNA homopolymers or purified cellular RNA forms assemblies in vitro analogous to stress granules. Remarkably, under conditions representative of an intracellular stress response, the mRNAs enriched in assemblies from total yeast RNA largely recapitulate the stress granule transcriptome. We suggest stress granules are formed by a summation of protein-protein and RNA-RNA interactions, with RNA self-assembly likely to contribute to other RNP assemblies wherever there is a high local concentration of RNA. RNA assembly in vitro is also increased by GR and PR dipeptide repeats, which are known to increase stress granule formation in cells. Since GR and PR dipeptides are involved in neurodegenerative diseases, this suggests that perturbations increasing RNA-RNA assembly in cells could lead to disease.

References

Oct 14, 2000·Annual Review of Cell and Developmental Biology·J G Gall
Jan 16, 2002·Current Biology : CB·Archa H FoxAngus I Lamond
Aug 15, 2002·Nucleic Acids Research·Neocles B LeontisEric Westhof
Mar 19, 2003·The Journal of Cell Biology·Helene TourrièreJamal Tazi
Sep 17, 2004·Molecular Biology of the Cell·Natalie GilksPaul Anderson
Oct 29, 2005·Circulation Research·Ami MankodiCharles A Thornton
Mar 8, 2006·The Journal of Cell Biology·Paul Anderson, Nancy Kedersha
Jun 28, 2006·Molecular Biology of the Cell·Anne-Sophie NicotJocelyn Laporte
Sep 20, 2006·Neuron·Michael A Kiebler, Gary J Bassell
Mar 30, 2007·Molecular Biology of the Cell·Ute NonhoffSylvia Krobitsch
Feb 23, 2008·Trends in Biochemical Sciences·Paul Anderson, Nancy Kedersha
Apr 15, 2008·Cell Host & Microbe·Carla J Beckham, Roy Parker
May 3, 2008·Science·Ugrappa NagalakshmiMichael Snyder
Sep 9, 2008·Journal of the American Chemical Society·Giuliano ZanchettaNoel A Clark
Mar 6, 2009·Genome Biology·Ben LangmeadSteven L Salzberg
May 23, 2009·Nature Reviews. Molecular Cell Biology·Paul Anderson, Nancy Kedersha
Jan 13, 2010·Molecular Cell·J Ross Buchan, Roy Parker
Oct 29, 2010·Genome Biology·Simon Anders, Wolfgang Huber
Jul 26, 2011·Database : the Journal of Biological Databases and Curation·Rhoda J KinsellaPaul Flicek
Jul 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Cathal McCannMani Ramaswami
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Jan 8, 2013·Virology·Lucas C Reineke, Richard E Lloyd
May 1, 2013·PLoS Biology·Kohila MahadevanAlexander F Palazzo
Nov 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tao ZuLaura P W Ranum
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Sep 28, 2014·Bioinformatics·Simon AndersWolfgang Huber
Dec 9, 2014·Biochimica Et Biophysica Acta·Paul AndersonPavel Ivanov
Mar 15, 2015·Cell·Vladimir PresnyakJeff Coller
Mar 25, 2015·The Journal of Cell Biology·Syam Prakash SomasekharanPoul H Sorensen
May 28, 2015·Proceedings of the National Academy of Sciences of the United States of America·Shana Elbaum-GarfinkleClifford P Brangwynne
Aug 19, 2015·The Journal of Cell Biology·Sven HennigArcha H Fox

❮ Previous
Next ❯

Citations

Oct 24, 2018·Molecular and Cellular Biology·Isabel CarrascosoJosé M Izquierdo
Feb 12, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Celeste EnoFrancisco Pelegri
May 3, 2019·Wiley Interdisciplinary Reviews. RNA·Jason SadekImed Eddine Gallouzi
Jul 27, 2018·The Journal of Biological Chemistry·Edward Gomes, James Shorter
Aug 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Lenzie FordLuana Fioriti
Oct 30, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Aleksej Drino, Matthias R Schaefer
Nov 14, 2019·Nucleic Acids Research·Yueying ZhangYiliang Ding
Oct 14, 2019·Traffic·Stephanie SpannlHyun O Lee
Dec 28, 2019·RNA·Anthony Khong, Roy Parker
Feb 26, 2020·Journal of Biomedical Science·Kuan-Wei Chen, Jun-An Chen
May 15, 2020·Nucleic Acids Research·Syam Prakash SomasekharanPoul H Sorensen
Jun 17, 2020·Emerging Topics in Life Sciences·Danielle A Adekunle, Arnaud Hubstenberger
Jun 24, 2020·Emerging Topics in Life Sciences·M Sankaranarayanan, Timothy T Weil
Jul 2, 2020·The Journal of Cell Biology·Kyle BegovichJames E Wilhelm
Jun 3, 2020·Cold Spring Harbor Symposia on Quantitative Biology·Giulia Ada Corbet, Roy Parker
Jun 5, 2020·Cold Spring Harbor Symposia on Quantitative Biology·Tucker J Carrocci, Karla M Neugebauer
Aug 23, 2019·Nature·Maria HondeleKarsten Weis
Aug 23, 2019·Scientific Reports·Paulo L OnuchicPriya R Banerjee
Oct 5, 2019·Nature Reviews. Neuroscience·Benjamin Wolozin, Pavel Ivanov
Apr 14, 2018·Science·Erin M LangdonAmy S Gladfelter
May 26, 2018·Science·Magdalini Polymenidou
Sep 28, 2018·Cell Communication and Signaling : CCS·Jonathan A Lindquist, Peter R Mertens
Feb 3, 2019·Cold Spring Harbor Perspectives in Biology·Briana Van Treeck, Roy Parker
Mar 31, 2019·Proceedings of the National Academy of Sciences of the United States of America·Steven BoeynaemsAaron D Gitler
Feb 11, 2020·Annual Review of Biophysics·Kevin RhineSua Myong
May 20, 2020·Viruses·Matthew J BrownswordHelena J Maier
Jun 6, 2020·Cellular and Molecular Life Sciences : CMLS·Vivek M Advani, Pavel Ivanov
Jul 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siran TianTatjana Trcek
Jun 6, 2018·Frontiers in Immunology·Lu LuEster Boix
Jul 12, 2018·Nucleic Acids Research·Jessica GreenwoodJulia Promisel Cooper
Sep 12, 2018·Annual Review of Microbiology·Erin M Langdon, Amy S Gladfelter
Feb 8, 2019·Communications Biology·Alan Herbert
Jul 5, 2019·Cells·Sergei A PirogovMikhail S Klenov
Mar 11, 2020·Cell Research·Xiang-Dong Fu
Jun 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Charles Bou-Nader, Jinwei Zhang
Jul 8, 2020·Nature Reviews. Molecular Cell Biology·Christine Roden, Amy S Gladfelter
Apr 20, 2018·The Journal of Cell Biology·Wessel van LeeuwenCatherine Rabouille
Jul 22, 2019·Nature Communications·Marina Garcia-Jove NavarroZoher Gueroui

❮ Previous
Next ❯

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