Abstract
We used RNA-sequencing (RNA-Seq) technology and an old hematopoietic stem and progenitor cells (HSPCs) model in vitro to analyze differential expressions of mismatch repair (MMR)-related genes in aged HSPCs, so as to explore the mechanism of DNA MMR injury in hematopoietic stem cells (HSC) aging. In this study, by combining RNA-seq data and National Center for Biotechnology Information database, we focus on six widely reported MMR genes MSH2, MSH3, MSH6, MLH1, PMS1, PMS2, and five MMR genes with closer ties to HSC aging Pcna, Exo1, Rpa1, Rpa2, and Rpa3 according to the genes functional classification and the related signaling pathway. It is concluded that MMR is closely related to HSC aging. This study provides experimental evidence for future researching MMR in HSC aging.
References
Jan 1, 1997·Annual Review of Biochemistry·M S Wold
Sep 3, 1999·Critical Reviews in Biochemistry and Molecular Biology·C IftodeJ A Borowiec
Feb 5, 2005·The EMBO Journal·Joanna M PrasherLaura J Niedernhofer
Mar 1, 2005·Cell·David B LombardFrederick W Alt
Oct 12, 2005·Experimental Gerontology·Kathryn AnnettYvonne Barnett
Feb 9, 2006·Chemical Reviews·Ravi R IyerPaul L Modrich
Dec 22, 2006·Nature·Laura J NiedernhoferJan H J Hoeijmakers
Oct 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Amitabh V NimonkarStephen C Kowalczykowski
Jan 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Joanna KlapaczLeona D Samson
Jun 12, 2009·The Journal of Biological Chemistry·Jochen Genschel, Paul Modrich
Feb 18, 2011·Genes & Development·Amitabh V NimonkarStephen C Kowalczykowski
Jun 29, 2012·Blood·Jonathan KenyonStanton L Gerson
Jul 12, 2016·Cell Cycle·Seok-Won JangJung Min Kim
Aug 30, 2016·International Journal of Stem Cell Research and Therapy·Jonathan KenyonStanton L Gerson
Nov 17, 2017·Blood·Gerald de Haan, Seka Simone Lazare
Apr 16, 2018·Stem Cells Translational Medicine·Rutulkumar PatelScott M Welford
May 31, 2018·Nucleic Acids Research·Sonoko IshinoHannu Myllykallio
Oct 3, 2018·Leukemia·Rutulkumar PatelScott M Welford
Citations
Mar 7, 2020·Aging Clinical and Experimental Research·Xiaolan LianLina Zhang
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Jianyang DuShaoshan Hu
Nov 25, 2020·Journal of Hematology & Oncology·Lei ZhangJiwang Zhang
Feb 3, 2021·DNA Repair·Alexandra M D'Amico, Karen M Vasquez