RNA Sequencing Identifies a Common Physiology in Vancomycin- and Ciprofloxacin-Tolerant Staphylococcus aureus Induced by ileS Mutations.

Antimicrobial Agents and Chemotherapy
Madhuri SinghKeiichi Hiramatsu

Abstract

Little is known about the mechanisms by which ileS mutations induce vancomycin tolerance in Staphylococcus aureus This study showed that transcriptome profiles were similar in vancomycin-tolerant mutants and the IleRS-inhibitor-treated parent. Notably, ileS and relA, which induce a stringent response, were upregulated. The same mechanism was responsible for cross-tolerance to vancomycin and ciprofloxacin. These findings suggest that the accumulation of uncharged isoleucyl-tRNA following ileS mutations in S. aureus was responsible for drug tolerance.

References

Oct 1, 1986·Antimicrobial Agents and Chemotherapy·E TuomanenA Tomasz
Apr 24, 2008·Molecular Microbiology·Matthew F TraxlerTyrrell Conway
Mar 6, 2009·Genome Biology·Ben LangmeadSteven L Salzberg
Mar 18, 2009·Bioinformatics·Cole TrapnellSteven L Salzberg
Jul 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Brian P EnglishJohan Elf
Nov 23, 2011·Antimicrobial Agents and Chemotherapy·Swantje ReissSusanne Engelmann
Jul 11, 2013·BMC Bioinformatics·Jianqiang SunKoji Kadota
Apr 29, 2014·Cell·Etienne Maisonneuve, Kenn Gerdes
May 3, 2014·Nature·Karyn Hede
Nov 14, 2015·Genome Announcements·Madhuri SinghKeiichi Hiramatsu
Mar 10, 2016·Proceedings of the National Academy of Sciences of the United States of America·Rebecca M CorriganAngelika Gründling
May 6, 2016·Molecular Microbiology·Wieland Steinchen, Gert Bange
Nov 18, 2016·Antimicrobial Agents and Chemotherapy·Madhuri SinghKeiichi Hiramatsu
Feb 12, 2017·Science·Irit Levin-ReismanNathalie Q Balaban
Jul 10, 2019·ACS Infectious Diseases·Joanne K Hobbs, Alisdair B Boraston
Feb 6, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Ekta Kamble, Karishma Pardesi

❮ Previous
Next ❯

Citations

Oct 16, 2020·The Journal of Infectious Diseases·Kazuhiko IkeuchiHiroshi Yotsuyanagi

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.