DOI: 10.1101/506246Dec 25, 2018Paper

RNA sequencing identifies dysregulated circular RNAs in early-stage breast cancer

BioRxiv : the Preprint Server for Biology
Vittal Rangan ArvindenSamson Mani

Abstract

Background: Breast cancer is a major cause of cancer related death in women worldwide. Molecular diagnostic markers that are detectable in early-stage breast cancer can aid in effective clinical intervention. Circular RNAs are a recently identified group of non-coding RNA with potential role in cancer development and progression. In this study, we aimed to identify circular RNAs specific for early stage breast cancer. Method: Circular RNA expression profile was analyzed in early-stage breast cancer tissues (N=5), matched normal counterparts (N=5) and absolute normal samples (N=5) by RNA-sequencing that enables a comprehensive analysis of RNA expression across the transcriptome. Two different algorithms, find\_circ and DCC were used to identify the differentially expressed circular RNAs. Results: A total of 58 and 87 circular RNAs were found to be differentially expressed by find\_circ and DCC algorithms, respectively, among which 26 circular RNAs were common. Hsa\_circ\_0001946 (CDR1-as) was found to be upregulated in early stage breast cancer along with other novel circular RNAs (hsa\_circ\_0008225, hsa\_circ\_0007766, hsa\_circ\_0016601). We also found that a few of the identified circular RNAs harbor microRNA binding sites w...Continue Reading

Related Concepts

Biological Markers
Malignant Neoplasm of Breast
Malignant Neoplasms
Cessation of Life
RNA
Up-Regulation (Physiology)
Woman
RNA, circular
Disease Progression
RNA, Untranslated

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