PMID: 7544309Aug 1, 1995Paper

RNA structure at high resolution

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
L X ShenI Tinoco

Abstract

Studies of RNA structural motifs at high resolution by NMR and X-ray crystallographic methods have provided many insights into the fundamental forces that give rise to the unique structural characteristics of RNA. Non-Watson-Crick purine-pyrimidine, purine-purine, and pyrimidine-pyrimidine base pairing, as well as base-phosphate and base-ribose hydrogen bonding, are important forces for folding and stabilizing RNA structures. Base stacking is as important in determining RNA conformations as hydrogen bonding interactions. With the noncanonical interactions, many single-stranded loop regions such as hairpin loops, bulge loops, and internal loops fold into well-defined secondary structures. Loop-loop and loop-helix interactions can produce tertiary structures such as pseudoknots. Also, single strands adjacent to helical regions can form tertiary contacts with base-paired nucleotides of the helices. As we learn more about the structures of the important motifs we can ask more specific questions about the mechanisms of RNA-mediated functions. Conformational flexibility rather than a specific shape of the RNA may be important for some biological reactions. However, knowledge of the structures and the ease of conformational change of ...Continue Reading

Citations

Mar 1, 1996·International Journal of Cancer. Journal International Du Cancer·R A GrahamJ Taylor-Papadimitriou
Jun 23, 2005·The Journal of Biological Chemistry·Vaishali HandaKaren Usdin
Jan 6, 2018·Frontiers in Molecular Biosciences·Greta PintacudaAndrea Cerase
Jul 5, 2013·Physical Chemistry Chemical Physics : PCCP·Alison J HobroNicholas I Smith
Mar 20, 2014·Chemistry : a European Journal·Changfeng HongKazuhiko Nakatani
May 12, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jana SefcikovaHong Li
Jan 1, 1997·Annual Review of Biophysics and Biomolecular Structure·P Brion, E Westhof
Apr 15, 2011·Nucleosides, Nucleotides & Nucleic Acids·Anthony D Saleh, Paul S Miller
Nov 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Furqan M FazalSteven M Block
Jan 17, 2003·Biotechnology and Bioengineering·Louise M BarnesAlan J Dickson
May 19, 2016·Journal of Molecular Biology·Kris Ann BakerPhilip R Cunningham
Apr 4, 2021·International Journal of Molecular Sciences·Sayuri SakuragiJun-Ichi Sakuragi
Oct 24, 1998·Journal of Molecular Biology·N B Leontis, E Westhof
Jun 25, 1999·Brain Research. Molecular Brain Research·M J GallagherK R Brunden
Jul 31, 2013·Progress in Biophysics and Molecular Biology·Sukanya Halder, Dhananjay Bhattacharyya
Aug 1, 1996·Chemistry & Biology·J FeigonF W Smith
Jun 8, 2013·The Journal of Physical Chemistry. B·Rachel N WittsMaria C Nagan
Jan 1, 1997·Annual Review of Biophysics and Biomolecular Structure·P J Hagerman

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