PMID: 6169983Aug 14, 1981Paper

RNA synthesis and degradation during preferential inhibition of protein synthesis by cobalt chloride in Escherichia coli K-12

Molecular Biology Reports
C Guha, A Mookerjee

Abstract

It has been observed that growth of Escherichia coli cells are inhibited when treated with cobalt chloride (300 microM). It has also been shown that CoCl2 preferentially inhibits translation without inhibiting the process of transcription (1, 2, 8). We report here, that during treatment of E. coli cells with CoCl2, both messenger RNA and stable RNA synthesis is slowed down about 2.5 folds. The rate of degradation of mRNA also decreases and both chemical and functional half-life of mRNA increases about 2.5 folds in Co-treated cells. This clearly shows that the process of transcription is also affected while translation is preferentially inhibited during CoCl2 treatment.

References

Mar 22, 1966·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·G S Stent
Nov 1, 1973·The Biochemical Journal·M R Blundell, D G Wild
Jan 28, 1968·Journal of Molecular Biology·H K Das, A Goldstein
Oct 28, 1968·Journal of Molecular Biology·R Lavallé, G De Hauwer
Feb 1, 1954·The Journal of Clinical Investigation·C L WISSEMANH L LEY

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Citations

Dec 27, 2005·Bioscience, Biotechnology, and Biochemistry·Ileana Cornelia FarcasanuTokichi Miyakawa
Mar 7, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Peter RittlerWolfgang H Hartl

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