RNA tales - how embryos read and discard messages from mom

Journal of Cell Science
Vladimir Despic, Karla M Neugebauer

Abstract

Following fertilization, embryos develop for a substantial amount of time with a transcriptionally silent genome. Thus, early development is maternally programmed, as it solely relies on RNAs and proteins that are provided by the female gamete. However, these maternal instructions are not sufficient to support later steps of embryogenesis and are therefore gradually replaced by novel products synthesized from the zygotic genome. This switch in the origin of molecular players that drive early development is known as the maternal-to-zygotic transition (MZT). MZT is a universal phenomenon among all metazoans and comprises two interconnected processes: maternal mRNA degradation and the transcriptional awakening of the zygotic genome. The recent adaptation of high-throughput methods for use in embryos has deepened our knowledge of the molecular principles underlying MZT. These mechanisms comprise conserved strategies for RNA regulation that operate in many well-studied cellular contexts but that have adapted differently to early development. In this Review, we will discuss advances in our understanding of post-transcriptional regulatory pathways that drive maternal mRNA clearance during MZT, with an emphasis on recent data in zebraf...Continue Reading

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Citations

Jul 5, 2018·FEBS Letters·Cecilia Lanny Winata, Vladimir Korzh
Apr 24, 2019·ELife·Qiushuang WuAriel Alejandro Bazzini
Aug 14, 2020·Wiley Interdisciplinary Reviews. RNA·Yong-Bin Yan
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Nov 28, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Matthias Bochtler, Humberto Fernandes
Jan 7, 2021·Genome Biology·Santiago Gerardo Medina-MuñozAriel Alejandro Bazzini
Jan 20, 2019·Developmental Biology·Andreas ZauckerKaruna Sampath

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