RNA thermosensors: how might animals exploit their regulatory potential?

The Journal of Experimental Biology
George N Somero

Abstract

The secondary and tertiary orders of RNA structure are crucial for a suite of RNA-related functions, including regulation of translation, gene expression and RNA turnover. The temperature sensitivity of RNA secondary and tertiary structures is exploited by bacteria to fabricate RNA thermosensing systems that allow a rapid adaptive response to temperature change. RNA thermometers (RNATs) present in non-coding regions of certain mRNAs of pathogenic bacteria enable rapid upregulation of translation of virulence proteins when the temperature of the bacterium rises after entering a mammalian host. Rapid upregulation of translation of bacterial heat-shock proteins likewise is governed in part by RNATs. Turnover of mRNA may be regulated by temperature-sensitive RNA structures. Whereas the roles of temperature-sensitive RNA structures similar to RNATs in Eukarya and Archaea are largely unknown, there would appear to be a potential for all taxa to adaptively regulate their thermal physiology through exploitation of RNA-based thermosensory responses akin to those of bacteria. In animals, these responses might include regulation of translation of stress-induced proteins, alternative splicing of messenger RNA precursors, differential expre...Continue Reading

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Citations

Jan 30, 2019·The Journal of Experimental Biology·Timothy M Healy, Patricia M Schulte
Jan 17, 2020·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·George N Somero
Dec 18, 2020·The Journal of Experimental Biology·Francis T C PanDonal T Manahan
Dec 14, 2018·Emerging Topics in Life Sciences·Liesbeth LemmensEveline Peeters
Sep 19, 2021·The FEBS Journal·Akhouri Kishore RaghawanGhanshyam Swarup
Oct 30, 2021·Biological Reviews of the Cambridge Philosophical Society·Yun-Wei DongGeorge N Somero
Nov 4, 2021·Proceedings of the National Academy of Sciences of the United States of America·Ming-Ling LiaoGeorge N Somero
Jan 18, 2022·Wiley Interdisciplinary Reviews. RNA·Akanksha SharmaRavi Pratap Barnwal

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