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RNA toxicity induced by expanded CAG repeats in Huntington's disease

Brain Pathology

Aug 17, 2016

Eulàlia Martí

Abstract

Huntington's disease (HD) belongs to the group of inherited polyglutamine (PolyQ) diseases caused by an expanded CAG repeat in the coding region of the Huntingtin (HTT) gene that results in an elongated polyQ stretch. Abnormal function and aggregation of the mutant protein has been typi...read more

Mentioned in this Paper

HTT gene
Huntington Disease
Transcript
Genetic Translation Process
Anabolism
Mutant Proteins
Biochemical Pathway
Establishment and Maintenance of Localization
Poly(A) Tail
HD protein, human
1
53
Paper Details
References
  • References56
  • Citations5
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RNA toxicity induced by expanded CAG repeats in Huntington's disease

Brain Pathology

Aug 17, 2016

Eulàlia Martí

PMID: 27529325

DOI: 10.1111/bpa.12427

Abstract

Huntington's disease (HD) belongs to the group of inherited polyglutamine (PolyQ) diseases caused by an expanded CAG repeat in the coding region of the Huntingtin (HTT) gene that results in an elongated polyQ stretch. Abnormal function and aggregation of the mutant protein has been typi...read more

Mentioned in this Paper

HTT gene
Huntington Disease
Transcript
Genetic Translation Process
Anabolism
Mutant Proteins
Biochemical Pathway
Establishment and Maintenance of Localization
Poly(A) Tail
HD protein, human
1
53

Similar Papers Found In These Feeds

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Paper Details
References
  • References56
  • Citations5
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