RNA virus-encoded microRNAs: biogenesis, functions and perspectives on application

ExRNA
Shoubin ZhanXi Chen

Abstract

MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression at the posttranscriptional level and play a crucial role in development and many diseases. The discovery of miRNAs has greatly expanded our understanding of the intricate scenario of genome-wide regulation. Over the last two decades, hundreds of virus-encoded miRNAs have been identified, most of which are from DNA viruses. Although the number of reported RNA virus-derived miRNAs is increasing, current knowledge of their roles in physiological and pathological processes has remained lacking. In this review, we discuss the biogenesis and biological functions of RNA virus- encoded miRNAs and their proposed roles in virus-host interactions and further underscore their potential value in the diagnosis and treatment of viral diseases.

References

Sep 26, 2003·Nature·Yoontae LeeV Narry Kim
Oct 22, 2003·Cell·Dianne S SchwarzPhillip D Zamore
Oct 22, 2003·Cell·Anastasia KhvorovaSumedha D Jayasena
May 1, 2004·Science·Sébastien PfefferThomas Tuschl
Sep 17, 2004·Nature·Victor Ambros
Dec 17, 2004·Retrovirology·Yamina BennasserKuan-Teh Jeang
Dec 17, 2004·Retrovirology·Shinya OmotoYoichi R Fujii
Feb 22, 2005·The Journal of General Virology·Shinya Omoto, Yoichi R Fujii
Mar 23, 2005·Nature Methods·Sébastien PfefferThomas Tuschl
Apr 5, 2005·Nature Genetics·Azra KrekNikolaus Rajewsky
May 3, 2005·Journal of Theoretical Biology·Jacob P Couturier, Robert S Root-Bernstein
Oct 15, 2005·Development·Tingting Du, Phillip D Zamore
Dec 31, 2005·Nucleic Acids Research·Sam Griffiths-JonesAnton J Enright
Mar 15, 2006·Trends in Microbiology·Venugopal Nair, Mihaela Zavolan
Sep 15, 2007·Journal of Virology·Jennifer Lin, Bryan R Cullen
Feb 27, 2008·Nucleic Acids Research·Dominique L OuelletPatrick Provost
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenrie P Y HuiJ S Malik Peiris
Jan 24, 2009·Nature Reviews. Molecular Cell Biology·V Narry KimMikiko C Siomi
Feb 18, 2009·Retrovirology·Zachary KlaseFatah Kashanchi
Oct 30, 2009·Trends in Immunology·Joseph Sriyal Malik PeirisJohn Malcolm Nicholls
Nov 3, 2009·Nature Immunology·Fuping YouZhengfan Jiang
Mar 3, 2010·PLoS Pathogens·Bryan R Cullen
May 19, 2010·Annual Review of Microbiology·Rebecca L Skalsky, Bryan R Cullen
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andrew VarbleBenjamin R tenOever
Jul 7, 2010·Molecular Cell·Yujing ZhangChen-Yu Zhang
Aug 14, 2010·Nucleic Acids Research·Harald RouhaChristian W Mandl
Sep 16, 2010·RNA·Jillian S ShapiroBenjamin R Tenoever
Nov 9, 2010·Communicative & Integrative Biology·Anoek ZomerD Michiel Pegtel
Feb 1, 2011·Virology·Adam Grundhoff, Christopher S Sullivan
Mar 29, 2011·Cold Spring Harbor Perspectives in Biology·Matthijs M JoreJohn van der Oost
Aug 23, 2011·Biochimica Et Biophysica Acta·D Michiel PegtelJaap M Middeldorp
Sep 14, 2011·Nucleic Acids Research·Nick C T SchopmanJoost Haasnoot
Jan 21, 2012·Blood·Willem Stoorvogel
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rodney P KincaidChristopher S Sullivan
Jan 12, 2013·PLoS Pathogens·Rodney P Kincaid, Christopher S Sullivan
Jan 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Nicolas RosewickAnne Van den Broeke

❮ Previous
Next ❯

Citations

May 9, 2021·Expert Review of Molecular Diagnostics·Sushila MaanNarender Singh Maan
Jun 24, 2021·Journal of Cellular and Molecular Medicine·Elham KarimiPegah Mousavi

❮ Previous
Next ❯

Methods Mentioned

BETA
immunoprecipitation

Software Mentioned

SOLiD

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Medicinal Chemistry
Man Lung YeungKuan-Teh Jeang
Journal of Clinical Bioinformatics
Guangchuang Yu, Qing-Yu He
Trends in Microbiology
Venugopal Nair, Mihaela Zavolan
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Yang ZhuoXiaofeng Wang
Cellular & Molecular Immunology
Peng QiFan Feng Bu
© 2021 Meta ULC. All rights reserved