RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena

Genes & Development
Xiaolu ZhaoYifan Liu

Abstract

RNAi and Polycomb repression play evolutionarily conserved and often coordinated roles in transcriptional silencing. Here, we show that, in the protozoan Tetrahymena thermophila, germline-specific internally eliminated sequences (IESs)-many related to transposable elements (TEs)-become transcriptionally activated in mutants deficient in the RNAi-dependent Polycomb repression pathway. Germline TE mobilization also dramatically increases in these mutants. The transition from noncoding RNA (ncRNA) to mRNA production accompanies transcriptional activation of TE-related sequences and vice versa for transcriptional silencing. The balance between ncRNA and mRNA production is potentially affected by cotranscriptional processing as well as RNAi and Polycomb repression. We posit that interplay between RNAi and Polycomb repression is a widely conserved phenomenon, whose ancestral role is epigenetic silencing of TEs.

References

Jun 1, 1994·Microbiological Reviews·D M Prescott
Aug 4, 1999·Trends in Genetics : TIG·R H PlasterkZ Ivics
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yuhua ShangMartin A Gorovsky
May 30, 2002·Nucleic Acids Research·Jeffrey D WuitschickKathleen M Karrer
Feb 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yifan LiuMartin A Gorovsky
May 20, 2005·Current Opinion in Cell Biology·Andrés Aguilera
Aug 12, 2005·Cytogenetic and Genome Research·J JurkaJ Walichiewicz
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Vladimir V Kapitonov, Jerzy Jurka
Mar 17, 2007·Nature Reviews. Genetics·R Keith Slotkin, Robert Martienssen
May 25, 2007·Nature·Shiv I S Grewal, Sarah C R Elgin
Jan 15, 2008·Trends in Genetics : TIG·Andrew B ConleyI King Jordan
Jun 7, 2008·Science·Yuya OgawaJeannie T Lee
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Chryssa KanellopoulouDavid M Livingston
Feb 26, 2009·Cell·Colin D Malone, Gregory J Hannon
May 28, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·David W ZehYoichi Ishida
Jul 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ahmad M KhalilJohn L Rinn
Feb 4, 2010·Genes & Development·Martin LeebAnton Wutz
Jul 10, 2010·Science·Miao-Chih TsaiHoward Y Chang
Nov 27, 2010·Nucleic Acids Research·Aron Marchler-BauerStephen H Bryant

❮ Previous
Next ❯

Citations

May 29, 2020·Cellular and Molecular Life Sciences : CMLS·Iwona RzeszutekMariusz Nowacki
May 8, 2021·Frontiers in Cell and Developmental Biology·Yongqiang LiuShan Gao
Jul 3, 2021·Trends in Genetics : TIG·Angélique DélérisSandra Duharcourt

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Cell
Mikel ZaratieguiR A Martienssen
Current Biology : CB
Kathleen Collins, Martin A Gorovsky
Current Opinion in Genetics & Development
Hirotsugu IshizuHaruhiko Siomi
© 2022 Meta ULC. All rights reserved