Abstract
alpha-actinin-4, originally identified as an actin-binding protein associated with cell motility, invasion, and metastasis of cancer cells, appears to be overexpressed in various human epithelial carcinomas, including colorectal, breast, esophageal, ovarian, and non-small cell lung carcinomas. The authors evaluated whether alpha-actinin-4 might be appropriate as a molecular target for cancer gene therapy. In 64 primary oral squamous cell carcinomas (OSCCs) and 10 normal oral mucosal specimens, and in seven human OSCC cell lines, alpha-actinin-4 expression was evaluated immunologically and correlations with clinicopathologic factors were examined. Overexpression of alpha-actinin-4 was detected in 38 of 64 oral squamous cell carcinomas (70%); significantly more frequently than in normal oral mucosa. The expression of alpha-actinin-4 was significantly associated with invasion potential defined by the Matrigel invasion assay. Cancer cell lines with higher alpha-actinin-4 expression had greater invasive potential. An RNAi-mediated decrease in alpha-actinin-4 expression reduced the invasion potential. These results indicated that the overexpression of alpha-actinin-4 was associated with an aggressive phenotype of OSCC. The study indi...Continue Reading
References
Aug 1, 1992·Genomics·A H BeggsN G Laing
Aug 1, 1990·The Journal of Cell Biology·C A OteyK Burridge
Jul 22, 1965·Biochimica Et Biophysica Acta·K Maruyama
Jul 1, 1965·Journal of Biochemistry·K Maruyama, S Ebashi
Jul 1, 1995·The Journal of Cell Biology·K A KnudsenM J Wheelock
Apr 1, 1994·Molecular and Cellular Biology·T NishiyamaY Takai
Sep 1, 1993·The Journal of Cell Biology·J L Rodríguez FernándezA Ben-Ze'ev
Dec 1, 1995·Human Pathology·A Peralta SolerH Salazar
Feb 21, 1998·American Journal of Otolaryngology·W L HicksD P Shedd
Apr 29, 1998·The Journal of Cell Biology·K HondaS Hirohashi
Feb 3, 2000·Oncogene·S N NikolopoulosR A Ross
Jan 25, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·B L ZioberR H Kramer
May 1, 2002·Nature Biotechnology·Thomas Tuschl
Jul 19, 2002·Journal of Cellular Physiology·Serenella M PupaElda Tagliabue
Oct 11, 2002·The Journal of Pathology·Agnes BánkfalviJozsef Piffkó
Nov 30, 2002·Oral Oncology·S SatoT Takata
Jul 3, 2003·The Laryngoscope·Donald G SessionsOmer Ahmad Chaudry
Apr 20, 2004·Cancer Cell·Li MaoVassiliki A Papadimitrakopoulou
May 4, 2004·Oncogene·Kazufumi HondaSetsuo Hirohashi
Sep 16, 2004·Nature Reviews. Molecular Cell Biology·Roberto BuccioneMark A McNiven
Jan 6, 2005·Gastroenterology·Kazufumi HondaSetsuo Hirohashi
Mar 16, 2005·Molecular Cancer Therapeutics·Yasusei KudoTakashi Takata
Mar 25, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shilpi AroraRanju Ralhan
May 14, 2005·Cancer Letters·Souichi YanamotoAkio Mizuno
Oct 6, 2005·Cancer Research·Yasuharu HayashidaTesshi Yamada
Nov 16, 2005·International Journal of Cancer. Journal International Du Cancer·Mitsuhiro TakenoyamaPierre G Coulie
Dec 8, 2006·Molecular & Cellular Proteomics : MCP·Tomohiko HaraTesshi Yamada
Jan 9, 2007·Oral Oncology·Souichi YanamotoAkio Mizuno
Sep 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sohei YamamotoOsamu Matsubara
Oct 26, 2007·Cancer·Li FuXin Yuan Guan
Jun 24, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Raúl González-GarcíaJosé L Gil-Díez Usandizaga
Citations
Aug 25, 2011·Applied Biochemistry and Biotechnology·Shi-Rou LimLay-Harn Gam
Aug 1, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R NoroT Yamada
Oct 23, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kevin J HamillJonathan C R Jones
Nov 10, 2013·PloS One·Sirpa SaloTuula Salo
May 21, 2013·World Journal of Gastroenterology : WJG·Dessy ChanJohnny Cheuk-On Tang
Feb 15, 2016·Pathology Oncology Research : POR·Shin-Ichi YamadaHiroshi Kurita
Aug 20, 2015·Cell & Bioscience·Kazufumi Honda
Mar 19, 2014·The Biochemical Journal·Kate S Foley, Paul W Young
Sep 13, 2014·PloS One·Geert A A Van RaemdonckXaveer W M Van Ostade
Jan 25, 2017·Oral Diseases·K YamashitaT Tsukuba
Apr 8, 2017·International Journal of Oral and Maxillofacial Surgery·T KakuyaK Honda
Jan 10, 2018·Oral Diseases·H SakamotoT Tsukuba
Aug 6, 2017·International Journal of Cancer. Journal International Du Cancer·Ilyes BeraniaApostolos Christopoulos
Feb 28, 2014·Cancer Medicine·Yukio WatabeKazufumi Honda
Feb 22, 2012·Histopathology·Sohei YamamotoOsamu Matsubara
Sep 17, 2019·Proteomics·Manuela Klingler-HoffmannPeter Hoffmann
Nov 27, 2019·Cells·Dmitri TentlerNikolai A Barlev
Aug 18, 2020·The Bulletin of Tokyo Dental College·Yusuke MatsuzakiTakahiko Shibahara
Apr 9, 2020·British Journal of Cancer·Teppei SuganoTesshi Yamada
Nov 12, 2020·American Journal of Physiology. Cell Physiology·Eleana ParajónDouglas N Robinson
Feb 10, 2021·Scientific Reports·Chiho HiragaKiyotaka Shiba
Jun 21, 2018·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Hirokazu ShojiKazufumi Honda
Apr 12, 2012·Journal of Cell Science·Richard P StevensonLaura M Machesky
Aug 27, 2021·Cytoskeleton·Lijun LiangYing Wang
Dec 1, 2021·Cancer Science·Rintaro NoroKaoru Kubota